The wettability and swelling of selected mucoadhesive polymers in simulated saliva and vaginal fluids

22. May 2017

22. May 2017 Abstract The surface properties play a particularly important role in the mucoadhesive drug delivery systems. In these...

Effect of Different Meltable Binders on the Disintegration and Dissolution Behavior of Zolmitriptan Oromucosal Fast Melt Tablets

22. February 2017

22. February 2017 Abstract Objective: Fast melt tablets and sublingual route have been widely used for providing quick onset of...

Development of enteric-coated fixed dose combinations of amorphous solid dispersions of ezetimibe and lovastatin: Investigation of formulation and process param

7. February 2017

07. February 2017 Abstract Enteric-coated fixed-dose combinations of ezetimibe and lovastatin were prepared by fluid bed coating aiming to avoid...

Thermal Processing of PVP- and HPMC-Based Amorphous Solid Dispersions

1. January 2017

Abstract Thermal processing technologies continue to gain interest in pharmaceutical manufacturing. However, the types and grades of polymers that can...

Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule

15. December 2016

15. December 2016 Abstract Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft...

Oral sustained-release suspension based on a lauryl sulfate salt/complex

24. October 2016

24. October 2016 Abstract The objective of this study was to evaluate the feasibility of lauryl sulfate (LS) salt/complex...

Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination

11. October 2016

The purpose of this work was to increase the solubility and the dissolution rate of itraconazole, which was chosen as...

Investigating the Use of Polymeric Binders in Twin Screw Melt Granulation Process for Improving Compactibility of Drugs

4. September 2016

Traditionally, the melt granulation for pharmaceutical products was performed at low temperature (<90°C) with high-shear granulators using low-melting waxy binders,...

SOLUBILITY AND PERMEATION STUDIES USING SOLUPLUS® AND HPMC WITH A BCS CLASS II AMORPHOUS DRUG

22. August 2016

22. August 2016 Summary of the Master Thesis Indomethacin (IND) is classified in class II of the Biopharmaceutics Classification System...

Rapid-Onset Sildenafil Sublingual Drug Delivery Systems: In Vitro Evaluation and In Vivo Pharmacokinetic Studies in Rabbits

21. March 2016

21. March 2016 The aim of the present study was to prepare sublingual delivery systems for sildenafil and evaluate its...

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