Stability-Enhanced Ternary Solid Dispersions with HPMC and Soluplus

24. September 2017

24. September 2017 Abstract The aim of this study was to evaluate a novel combination of hydroxypropyl methylcellulose phthalate (HPMCP-HP-50) and Soluplus®polymers...

Hot Melt Extrudates Formulated Using Design Space: One Simple Process for Both Palatability and Dissolution Rate Improvement

Hot melt extrudates formulated using design space: improved palatability and dissolution

31. August 2017

31. August 2017 This work aimed to obtain an optimized itraconazole (ITZ) solid oral formulation in terms of palatability and...

Effect of amphiphilic graft co-polymer-carrier on physical stability of bosentan nanocomposite: Assessment of solubility, dissolution and bioavailability

28. June 2017

28. June 2017 Abstract Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH)....

A Comparative Assessment of Nanocomposites vs. Amorphous Solid Dispersions Prepared via Nanoextrusion for Drug Dissolution Enhancement

8. June 2017

08. June 2017 Abstract Nanoextrusion was used to produce extrudates of griseofulvin, a poorly water-soluble drug, with the objective of...

The wettability and swelling of selected mucoadhesive polymers in simulated saliva and vaginal fluids

22. May 2017

22. May 2017 Abstract The surface properties play a particularly important role in the mucoadhesive drug delivery systems. In these...

Effect of Different Meltable Binders on the Disintegration and Dissolution Behavior of Zolmitriptan Oromucosal Fast Melt Tablets

22. February 2017

22. February 2017 Abstract Objective: Fast melt tablets and sublingual route have been widely used for providing quick onset of...

Development of enteric-coated fixed dose combinations of amorphous solid dispersions of ezetimibe and lovastatin: Investigation of formulation and process param

7. February 2017

07. February 2017 Abstract Enteric-coated fixed-dose combinations of ezetimibe and lovastatin were prepared by fluid bed coating aiming to avoid...

Thermal Processing of PVP- and HPMC-Based Amorphous Solid Dispersions

1. January 2017

Abstract Thermal processing technologies continue to gain interest in pharmaceutical manufacturing. However, the types and grades of polymers that can...

Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule

15. December 2016

15. December 2016 Abstract Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft...

Oral sustained-release suspension based on a lauryl sulfate salt/complex

24. October 2016

24. October 2016 Abstract The objective of this study was to evaluate the feasibility of lauryl sulfate (LS) salt/complex...

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