MEDELPHARM

MEDELPHARM just announced the STYL'One University Contest, offering universities the chance to win a STYL'One Nano Compaction Simulator on a free loan for two years. This contest highlights their commitment to supporting academic institutions and fostering scientific innovation. Why Choose the…
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Abstract This study aims to decouple the effect of dwell time and strain rate on tablet strength and cracking behavior. Using a hydraulic compaction simulator, dwell time and strain rate were isolated from other parameters in the compaction cycle so that their independent contributions to…
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Abstract Current oral formulations of macromolecules including peptides typically rely on single permeation enhancer (PE) to promote absorption and thus bioavailability. In this work, we combined two PEs, namely sodium N- caprylate (SNAC) and sodium caprate (C10), in one tablet formulation to…
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Abstract The pharmaceutical industry is striving to develop innovative and promising tools, increasingly embracing new data-driven approaches, to understand, improve and accelerate the drug product development process. While extended release (ER) oral formulations offer a number of advantages,…
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Abstract Tablet coating with aqueous solvents represents a well-established environmentally sustainable alternative to coatings based on organic solvents. However, this practice requires a careful evaluation of potential quality issues, such as increased porosity and crack formation stemming from…
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Abstract The viability of probiotic microorganisms is essential for their health-promoting effects and must be preserved in the best possible way during the production of the final dosage form, such as tablets. This applies to both drying and tableting. Saccharomyces cerevisiae is spray-dried…
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Abstract Ribbon porosity is a critical parameter to monitor in the roller compaction process. In this study, six techniques for measuring the porosity of solid compacts, i.e., manually by caliper (Caliper), X-ray microtomography (µCT), off-line near-infrared spectroscopy (NIR), laser triangulation…
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This poster was presented at the DDF Summit Conference 2024 by Valentyn MOHYLYUK, Zoltán Márk HORVÁTH, Kirils KUKULS, Liga LAUBERTE, Artūrs PAULAUSKS from Rīga Stradiņš University: Introduction Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is…
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This poster was presented at the AAPS 2024 by BASF, KORSCH and MEDELPHARM: PURPOSE The aim of this study was to optimize the formulation and production process of pharmaceutical tablets using an integrated approach involving algorithm-based formulation tool (ZoomLab®) and a compaction simulator…
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Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated…
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