MEDELPHARM

Introduction Using in tablet formulations microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4 ) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural-mechanical properties of tablets.…
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Introduction High-drug-loaded tablets and capsules are desirable and are manufactured using granulation as an additional step. Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is gaining popularity. PEG 8000 being one of the most popular…
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Abstract Using microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural–mechanical properties of tablet formulations. Thus, mixtures of…
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Abstract Previous work demonstrated the benefits of dry coating fine-grade microcrystalline cellulose (MCC) for enabling direct compression (DC), a favored tablet manufacturing method, due to enhanced flowability while retaining good compactability of placebo and binary blends of cohesive APIs.…
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News-Release MEDELPHARM S.A.S, March 28th 2023 Beynost, France: – Research-based manufacturer and powder compaction specialists MEDELPHARM S.A.S. is collaborating with the Centre for Continuous Manufacturing and Advanced Crystallization (CMAC) future manufacturing research hub in Glasgow, UK, on…
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Compaction simulators are a key technology allowing scientists to develop formulations and troubleshoot tablet defects. It means that formulation scientists or tech transfer engineers can assess the influence of process parameters on tablet properties to preempt risk during scale-up or to solve…
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The STYL’One Nano is the revolutionary benchtop R&D tablet press for demanding formulation scientists. Characterize your API and develop your single layer formulation with only a few grams of powder! Technical highlights: ✔ Benchtop model compact and mobile with a small footprint ✔ Driven…
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MEDELPHARM is organising a new webinar on Tuesday February 28th, 2022 - 3:00pm CET. See the webinar topic and what you can learn in the webinar. The webinar on "Assessing temperature influence on tablet quality attributes" will highlight the following: Introduction of a newly developed…
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The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal silica, Syloid® XDP and Neusilin® US2) through a screening plan. The enhancement of…
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Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects of temperature and compaction pressure on tablet…
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