MEDELPHARM

Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects of temperature and compaction pressure on tablet…
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Powder processing research and development (R&D) has its challenges, with experienced scientists and students alike coming across hurdles even when they have the best equipment. Rather than struggling alone, the key is collaboration. As a tablet instrumenting company, MEDELPHARM is more than…
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CPHI worldwide opens its doors again. This year in Frankfurt at the Messe Frankfurt. In two weeks, from 1st to 3rd November, you can finally have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE and BioProduction will be held together with CPHI. The…
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Instrumented die is used to measure maximum die-wall pressure (MDP) and residual die-wall pressure (RDP) during powder compaction. This document from MEDELPHARM aims to provide a methodology to characterize powders with this device. Introduction During tablet development, people study ejection…
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Powder granulation is commonly used in the pharmaceutical industry to improve flowability and compactibility of powders. In this case our customer wanted to develop a new direct compression grade of excipient produced by granulation. This paper presents the methodology of MEDELPHARM Science…
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During the development of a new drug, active materials are often available in small quantities for cost or process reasons. However, scientists have to understand their deformation behavior to design the best formulation possible and find suitable process parameters for production. Compaction…
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In the early stages of drug development, APIs are often available in limited amount. However, scientists have to foresee the impact of compaction parameters on tablet attributes. In fact, tablet quality such as its hardness depends on several process parameters including the compression speed,…
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Internal lubrication with magnesium stearate (MgSt) is associated with a reduced tensile strength and prolonged disintegration and dissolution times. In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The…
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Formulation development and technical transfer from lab to production can be challenging and requires a deep knowledge of your formulation. The integrated and intuitive data analysis features drive formulators and scientists in their decision-making process with build-in graphs and reports to…
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Particle morphology influence on tablet characteristics Excipients, APIs or formulations can be processed in different ways, thus resulting in different properties. Research has been performed to improve powder properties including powder flow, powder density, particle size distribution and…
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