From June 9 to 11, 2025, MEDELPHARM and KORSCH took part in the Compaction Simulation Forum (CSF) in San Francisco. Known for their leadership in compaction simulation, both companies used this year’s event to share innovative research through scientific posters, focusing on real manufacturing challenges and future directions in tablet development.
First Poster: The role of temperature on tablet attributes
Adrien Pelloux, Application Lab Manager at MEDELPHARM, presented the poster titled “Impact of temperature on tablet critical quality attributes.“ Using the heated die system of the STYL’One Evo Compaction Simulator, he explored how elevated temperatures (up to 50 °C) can affect tablet characteristics such as:
- Sticking: strong increase in sticking at higher temperatures
- Compression pressure: lower pressure needed to achieve target hardness
- Robustness: noticeable quality differences between tablets pressed at 20 °C vs. 50 °C
These results show that temperature should be considered a key development parameter, especially when working with heat-sensitive or sticky formulations. Including temperature stress tests early in the development process can help avoid issues during scale-up and manufacturing.
Second Poster: Personalized bilayer tablets with pTAB
Dr. Moritz Rosch, Process Specialist at KORSCH AG, presented the pTAB concept – a personalized bilayer tablet that enables adjustable dosing without changing tablet size or shape. His research used a customized die-filling strategy and a 3D-printed feeding wheel to create tablets delivering between 50 and 350 mg of ibuprofen.
Unlike 3D printing, this method is scalable, efficient, and safe—making it suitable for hospital pharmacies or individualized therapies. It offers a new way to produce dose-flexible tablets using standard manufacturing tools.
STYL’One Compaction Simulators featured in other poster sessions
The STYL’One Evo and STYL’One Nano also played a key role in several other research posters and talks presented at CSF 2025, including:
- Comparing compaction simulator and rotary presses at the compaction stage : some ideas about the “hidden” challenges in compaction simulation by the University of Bordeaux
- Development of a high-drug load, functionally coated pediatric mini-tablet formulation using the STYL’One Nano Compaction Simulator by AustinPx
- Frontiers in powder compaction research by the University of Minnesota
- Bridging bench scale to pilot scale in dry granulation using compaction simulator with model based approach by Serán Bioscience
These presentations show the broad impact of compaction simulation in both academic and industrial settings.
Supporting innovation from lab to production
The 2025 Compaction Simulation Forum confirmed the growing role of compaction simulation tools in solving practical development problems and enabling new dosage form innovations. MEDELPHARM and KORSCH continue to support the pharmaceutical community with powerful R&D compaction simulators that help reduce risk, improve decision-making, and bring better medicines to market faster.
Source: MEDELPHARM
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