Hydrophobic deep eutectic solvent (HDES) as oil phase in lipid-based drug formulations

16. July 2024

There is increasing pharmaceutical interest in deep eutectic solvents not only as a green alternative to organic solvents in drug...

Stability of Dexamethasone during Hot-Melt Extrusion of Filaments based on Eudragit® RS, Ethyl Cellulose and Polyethylene Oxide

4. July 2024

Hot-melt extrusion (HME) potentially coupled with 3D printing is a promising technique for the manufacturing of dosage forms such as...

Comparison of two self-nanoemulsifying drug delivery systems using different solidification techniques for enhanced solubility and oral bioavailability of poorly water-soluble celecoxib

3. July 2024

In this study, we aimed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) and a solid self-nanoemulsifying granule system...

Dual drug-loaded polymeric mixed micelles for ovarian cancer: Approach to enhanced therapeutic efficacy of albendazole and paclitaxel

24. June 2024

Chemotherapy resistance remains a significant challenge in treating ovarian cancer effectively. This study addresses this issue by utilizing a dual...

Carbomer Hydrogels with Microencapsulated α-Tocopherol: Focus on the Biocompatibility of the Microcapsules, Topical Application Attributes, and In Vitro Release Study

28. May 2024

The microencapsulation of α-tocopherol based on the complex coacervation of low-molecular-weight chitosan (LMWC) and sodium lauryl ether sulphate (SLES) without...

Enhancing breast cancer treatment: Comprehensive study of gefitinib-loaded poloxamer 407/TPGS mixed micelles through design, development, in-silico modelling, In-Vitro testing, and Ex-Vivo characterization

18. May 2024

Abstract Breast cancer continues to pose a substantial global health challenge, emphasizing the critical need for the advancement of novel...

A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric micelles: Ocular application for the delivery of neuroprotective compounds to the posterior eye segment

10. May 2024

Abstract TPGS (D-α-tocopheryl polyethylene glycol 1000 succinate) polymeric micelles show interesting properties for ocular administration thanks to their solubilization capability,...

New services offered by PMC Isochem

6. May 2024

PRESS RELEASE PMC Isochem is extending its R&D capabilities offering additional services for analytical development, formulation and bioengineering to external...

Fig.1 Phase solubility curve of efavirenz with TPGS (0.001-4% range) aqueous solutions

Amorphous – state Characterization and Dissolution Behaviour of Efavirenz – Tocopheryl Polyethylene Glycol Succinate (TPGS)-1000 Solid Dispersions

22. April 2024

ABSTRACT The aim of the present investigation was to enhance the aqueous solubility and dissolution rate of a poorly soluble...

Lipid-coated nanocrystals of paclitaxel as dry powder for inhalation: Characterization, in-vitro performance, and pharmacokinetic assessment

6. April 2024

Abstract Background Nanocrystals can be produced as a dry powder for inhalation (DPIs) to deliver high doses of drug to...

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