Formulation, optimization and evaluation of vitamin E TPGS emulsified dorzolamide solid lipid nanoparticles

9. January 2022

Herein, we designed this research to develop dorzolamide (DRZ) encapsulated solid lipid nanoparticles (SLNs) for ocular administration. The DRZ-SLNs were fabricated by ultrasonic emulsification...

A Customized Screening Tool Approach for the Development of a Self-Nanoemulsifying Drug Delivery System (SNEDDS)

2. January 2022

The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying drug delivery...

Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion

2. December 2021

The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we...

Formulation of ternary genistein β-cyclodextrin inclusion complex: In vitro characterization and cytotoxicity assessment using breast cancer cell line

11. November 2021

Genistein (GT) is a poorly water-soluble flavonoid and reported for different biological activity. The present work was designed to prepare...

Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral Drug Bioavailability and Patient Compliance Implications

In vivo evaluation of a novel zero order drug releasing transdermal system of rotigotine

7. October 2021

Background: Rotigotine is a new non-ergolinic dopamine agonist used in the treatment of Parkinson's disorder and restless legs syndrome. It...

Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates Micellar Solubilization In Vitro, but In Vivo Performance Remains Superior with Pure Sesame Oil Vehicle

2. September 2021

Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation....

Preparation of Silymarin–quercetin Loaded Nanoparticles by Spontaneous Emulsification Solvent Diffusion Method Using D-alpha-tocopheryl Poly (Ethylene Glycol) 1000 Succinate

5. April 2021

Silymarin, a flavonolignan, derived from Silybum marianum, family Asteraceae has long been used as a hepatoprotective remedy. Silymarin has cytoprotective...

TEM images of Apig incorporated into BSFL oil NEs with SOR 60%, oil content 1%, and surfactant ratios of HL/TPGS = (a) 0/100, (b) 50/50, and (c) 100/0. TEM images of Apig incorporated into AV oil NEs with the same composition ratios as described above as surfactant ratios of HL/TPGS = (d) 0/100, (e) 50/50, (f) 100/0.

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery

5. April 2021

Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor...

Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma

16. March 2021

Despite its proven efficacy in diverse metabolic disorders, quercetin (QU) for clinical use is still limited because of its low...

Cilostazol Solubilization and Stabilization Using a Polymer-Free Solid Dispersion System

14. January 2021

The development of pH-independent drugs is difficult because it involves improvements in their solubility and dissolution (%) in solubilizer. In...

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