Structural and thermal analysis of cannabidiol orodispersible formulation
Cannabidiol (CBD) is an alkaloid that can be found in the Cannabis species, currently used in United States of America under the name of Epidiolex®, which was approved by Food and Drug Administration (FDA) for seizures treatment. The purpose of this study was to investigate the structural characteristics of the raw materials and to compare 2 film formulations with different analytical methods.
In order to differentiate the structural properties, the following methods were used: X-ray powder diffraction (XRPD) and Fourier transform-infrared (FTIR) spectroscopy. The thermal properties of the raw materials and films was also obtained using differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA). As in the case of structural properties for the thermal decomposition, two films formulations that presented the highest differences were selected. Thermal analysis, FTIR and XRPD were utilized to present the characteristics of the raw materials and the selected orodispersible films.
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Materials: The materials used were: CBD 99.5% purity, Trigal Pharma (Austria), Hypromellose (Vivapharm HPMCE3) which was a kind gift from JRS Pharma (Germany). The other substances used were: citric acid (CA) Fooding (France), sorbitol (SRB) Falken Trade GmbH, (Germany), propylene glycol (PG) SKC Korea, (South Korea) and peach flavour Carmi Flavor and Fragrance (United States of America).
Article information: ROBERT-ALEXANDRU VLAD, TAMÁS SOVÁNY, KATALIN KRISTÓ, YOUSIF H-E.Y.
IBRAHIM, ADRIANA CIURBA, ZOLTÁN AIGNER, DANIELA LUCIA MUNTEAN, GÉZA REGDON JR.. FARMACIA, 2021, Vol. 69, 3.
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