Parteck® TA (Calcium Carbonate): Enhanced opacity with ideal particle properties

Titanium dioxide is extensively used in solid dosage forms as an opacifier and colorant. Due to regulatory developments and restrictions by authorities, formulators are increasingly interested in titanium dioxide-free solutions for both dietary supplements and medicinal products. Uniform colored and white coatings applied to tablets not only have an aesthetic function but also improve patient compliance.

Parteck^® TA excipient – Mercks titanium dioxide alternative – has been developed to address the need for an appealing white finish that does not use titanium dioxide. Its unique morphology and designed particle size distribution ensures enhanced opacity, even for challenging pre-colored tablets cores.

This mineral pigment performs excellently when used in HPMC- and PVA-based film coatings for immediate release tablets, thereby allowing higher pigment concentrations while maintaining high process efficiency. An ideal choice of film coating agent is Parteck^® COAT (art. 141517), a PVA-based excipient that is even able to achieve increased opacity compared to standard HPMC-containing formulations.

Parteck^® TA helps you to achieve a level of covering and whiteness comparable to TiO2-containing film coatings without affecting your tablets’ performance, making it a suitable alternative to titanium dioxide.

Parteck® TA (Calcium Carbonate)

High process efficiency due to lower viscosity of the spraying liquid

Enables an appealing and uniform tablet appearance

Enhanced opacity due to tailored particle size distribution and unique morphology

General description

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Due to regulatory developments, there is an increasing interest in titanium dioxide-free solutions for the coloring of solid dosage forms. Parteck^® TA – our titanium dioxide alternative – is a mineral and nature-identical pigment specifically developed for the use in tablet film coatings. It helps to achieve a level of covering and whiteness comparable to titanium dioxide film coatings without affecting your tablets’ performance. The enhanced opacity is ensured by its unique morphology and designed particle size distribution

Benefits of Parteck^®TA

Mineral and nature-identical pigment
GRAS, and compliant with Ph Eur, BP and USP
Our Emprove^® documentation facilitates qualification, risk assessment, and process optimization
Excellent compatibility with HPMC and PVA film coatings (including our Parteck^® COAT)
High process efficiency due to lower viscosity of the spraying liquid
Enables an appealing and uniform tablet appearance
Enhanced opacity due to tailored particle size distribution and unique morphology

Download also the Parteck® TA (Calcium Carbonate) SDS PDF here Parteck TA_SDS

Source: Merck, Website https://www.sigmaaldrich.com/DE/en/campaigns/parteck-ta

Parteck® TA (Calcium Carbonate): Enhanced opacity with ideal particle properties

General description

Application

Benefits of Parteck® TA

Benefits of Parteck^®TA