Poorly Water-Soluble Drugs and Formulation Strategy to Improve Oral Bioavailability

Poor water solubility of a drug is a tough and difficult task for researchers and pharmaceutical scientists during the formulation and development of dosage forms. Poor drug solubility often leads to inadequate and variable bioavailability. The properties of drugs cause problems in drug dissolution and its rates are solubility, particle size, polymorphism, salt form, complexation, wettability, etc.

The improvement of drug solubility there by its oral bioavailability remains one of most challenging aspects of drug formulation process mostly for oral drug administration and the oral bioavailability will be governed by various parameters including dissolution rate, aqueous solubility, drug permeability, pre-systemic metabolism and susceptibility.

To improve solubility and rate of dissolution, there are many approaches available like pH adjustment, particle size reduction, sono-crystallization, inclusion complexation, liquid solid methods, solid dispersion methods, self-emulsifying method, supercritical fluid processes, freeze drying method, spray drying method, hot melt extrusion method etc. Selection of right technique is the key to improve the drug dissolution and bioavailability and it helps to avoid the rejection of recent chemical entities because of low solubility. More on novel drug delivery technologies

The book covers the following chapters

1. Buccal and Intraoral Drug Delivery: Potential Alternative to Conventional Therapy

   Bazigha K. Abdul Rasool, Aliasgar Shahiwala

   Pages 29-71
2. Oral Controlled Release Systems: Current Strategies and Challenges

   Priyanka Bhatt, Deepa Patel, Ankita Patel, Akanksha Patel, Aishwarya Nagarsheth

   Pages 73-120
3. Peyer’s Patch: Targeted Drug Delivery for Therapeutics Benefits

   Rakesh P. Patel, Pranav Shah, Kalyani Barve, Nikunjana Patel, Jaimini Gandhi

   Pages 121-149
4. Colonic Drug Delivery Systems as Multiunit Potential: Therapeutic Strategies and Opportunities

   Naazneen Surti, Ashok Mahajan, Jitendra Amrutiya

   Pages 151-181
5. Parenteral Controlled and Prolonged Drug Delivery Systems: Therapeutic Needs and Formulation Strategies

   Imran Vhora, Denish Bardoliwala, Saketh Reddy Ranamalla, Ankit Javia

   Pages 183-260
6. Transdermal Drug Therapy: Emerging Techniques and Improved Patient Compliance

   Avinash Kumar Seth

   Pages 261-289
7. Inhalation Drug Therapy: Emerging Trends in Nasal and Pulmonary Drug Delivery

   Manisha Lalan, Hemal Tandel, Rohan Lalani, Vivek Patel, Ambikanandan Misra

   Pages 291-333
8. Ophthalmic and Otic Drug Administration: Novel Approaches and Challenges

   Ankita Desai, Manish Shukla, Furqan Maulvi, Ketan Ranch

   Pages 335-381
9. Approaches in Barriers, Modifications, Route of Administrations, and Formulations of Therapeutic Agents for Brain Delivery

   Arun Kumar Kotha, Saikat Ghosh, Neeraja Komanduri, Rui Wang, Subhas Bhowmick, Mahavir Bhupal Chougule

   Pages 383-401
10. Opportunities and Challenges in Targeted Carrier-Based Intracellular Drug Delivery: Increased Efficacy and Reduced Toxicity

    Sagar Dhoble, Shrikant Dhage, Sreeranjini Pulakkat, Vandana B. Patravale

    Pages 403-431