Coating Systems and Additives

Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a poorly water soluble molecule, with reduced oral…
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It is still a major challenge to remove tumor cells and fill bone defects after tumor resection. Combined with the 3D printing technology, the composite bioceramics scaffolds were fabricated with interconnected porous magnesium-doped wollastonite (CSi-Mg) scaffolds as the architecture and…
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To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The dry coating performed with different apparatuses (a batch-type high-speed shear mixer (Mechanomill) and a…
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Film-coating agent formulated without TiO2, aluminium and artificial colors Current solutions in tablet coating make it hard to both meet the growing demand for naturalness from consumers and to comply with stricter regulations, especially in Europe. SEPIFILM™ NATurally COLored by Seppic are…
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Use of high melting point solid vegetable oils in encapsulation processes Introduction to encapsulation Encapsulation relates to technologies that enable the incorporation of a compound into individualized small particles. Depending on the process applied, these particles can have…
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Our broad range of formulation products covers excipients for solid, semi-solid and liquid dosage forms for small and large molecules. Additionally, we offer a portfolio of drug delivery compounds (DDCs), as well as solutions for solubility enhancement and controlled release. Benefit from our…
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Amorphous solid dispersions (ASDs) have been widely utilized to enhance the bioavailability of pharmaceutical drugs with poor aqueous solubility. The role of various excipients on the amorphous drug to crystalline form conversion in ASDs has been widely documented. However, there has been no…
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According to the Quality by Design (QbD) concept, Design of Experiment (DoE) was used to indicate critical process parameters and optimize the fluid bed coating of minitablets in a laboratory size batch. Full factorial design was employed to increase knowledge of the process for three kinds of…
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Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets. In this study, immediate-release film-coated tablets…
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Colonic targeting of orally applied therapeutic drugs remains a challenge. Tablet coatings relying on gastrointestinal pH and colonic bacterial enzymes as triggers in association with an inner alkaline layer are expected to improve targeting efficiency. Mesalazine release from three differently…
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