Coating Systems and Additives

Over the past decades, increasing interests took place in the realm of drug delivery systems. Beyond treating intestinal diseases such as inflammatory bowel disease, colon targeting can provide possible applications for oral administration of proteins as well as vaccines due to the lower enzymatic…
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Protecting moisture sensitive substances from environmental moisture is one of the biggest challenges in the pharmaceutical and nutritional supplements industry. Coating the tablet core with a suitable film coating therefore plays an important role in achieving a sufficient moisture barrier. It…
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Oral multiparticulate systems are often the ‘go to’ solution for flexible dosing, especially in cases where a degree of functionality, such as taste masking or modified release, is required from the formulation. One of the preferred methods of adding functionality to multiparticulates is by fluid…
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Purpose Recent ban of titanium dioxide (TiO2; E171) for the use in food and nutritional supplements (European Commission). The regulation includes a commitment to review the necessity of titanium dioxide as a white colorant in medicinal products1. It is challenging to find a suitable…
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Abstract Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to the colon requires considered formulation development, as both oral and rectal dosage forms can encounter…
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Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a poorly water soluble molecule, with reduced oral…
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It is still a major challenge to remove tumor cells and fill bone defects after tumor resection. Combined with the 3D printing technology, the composite bioceramics scaffolds were fabricated with interconnected porous magnesium-doped wollastonite (CSi-Mg) scaffolds as the architecture and…
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To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The dry coating performed with different apparatuses (a batch-type high-speed shear mixer (Mechanomill) and a…
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Film-coating agent formulated without TiO2, aluminium and artificial colors Current solutions in tablet coating make it hard to both meet the growing demand for naturalness from consumers and to comply with stricter regulations, especially in Europe. SEPIFILM™ NATurally COLored by Seppic are…
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Use of high melting point solid vegetable oils in encapsulation processes Introduction to encapsulation Encapsulation relates to technologies that enable the incorporation of a compound into individualized small particles. Depending on the process applied, these particles can have…
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