Minerals as Excipients – Dr. Paul Lohmann

The major component of ingredients in pharmaceutical products in terms of volume is not the active ingredient itself, it is the excipient. Excipients assist in the administration of an ‘active’ substance that typically may not be easily administered or absorbed by the patient.

Mineral Salts as excipients are of specific importance, since they largely determine the structure of solid dosage forms and stabilize the chemical properties in liquid pharmaceutical forms.

Excipients have well-defined functions, which significantly influence the processability, stability and control the release of the drug product. Therefore, the selection of excipients is crucial to ensure that the drug substance is stable and has
desired pharmacokinetic properties, adhering to strict standards and regulations.

Produced for Functionality

Minerals as Excipients

The following reference tables are based on USP 43 – NF 381. The grouping of excipients by functional category is intended to summarize commonly identified purposes that these Mineral Salts as excipients serve in drug product formulations.

Antioxidant

Coating Agent

Emollient

Wet Binder

These are just 4 of 13 salts themes.

Tailor-made Solutions for state-of-theart Applications

There is an ongoing trend in the industry to reduce process complexity. Therefore, we offer product lines which address this actual trend.

Product line Low in Endotoxins

Dr. Paul Lohmann® offers excipients even in Low in Endotoxins pharmaceutical grades which are applied in parenteral preparations such as infusions or injections. These highly sensitive routes of administration require highest purity standards, which are fulfilled by our Quality by Design (QbD) approach. A dedicated purpose built GMP certified plant ensures the production of excipients meeting highest purity. Biopharmaceuticals, vaccines and blood plasma derived medicines utilize Phosphates and Citrates as excipients to achieve the required pH-value or EDTAs to stabilize the drug substance. Dr. Paul Lohmann® Low in Endotoxin Mineral Salt excipients enable a seamless integration into the production process and reduce process complexity.

Product Modification

 

See the full brochure on “Minerals as Excipients” here

(click the picture to download the brochure)

Source: Dr. Paul Lohmann brochure “Minerals as Excipients”

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