Direct Compression of Lactase Tablets with PROSOLV® EASYtab Nutra

The aim of this study was the development of lactase tablets that can be produced by direct compression. In order to avoid stability problems of the enzyme lactose, caused by high temperature and moisture, direct compression is the most suitable tableting process.

The performance of pure lactase powder in terms of lactase activity, ejection force during compression as well as functional tablet characteristics was investigated and compared to a blend of lactase powder and 30 % of the high functionality excipient PROSOLV EASYtab ® Nutra CM. Furthermore, the performance of the PROSOLV EASYtab ® based formulation was compared to marketed lactase tablets.

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