Hot-melt extrusion

Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility....

Most of the promising drugs in development channels are poorly water-soluble drugs which limit formulation approaches, clinical application because of...

The selection of an appropriate matrix for the preparation of amorphous extrudate in hot-melt extrusion (HME) deals with the study...

Amorphous solid dispersions can improve the solubility and dissolution rate of poorly soluble drugs. However, residual crystallinity can adversely affect...

This work aimed to use hot-melt extrusion (HME) and dual fused deposition modeling (FDM) 3D printing technology to develop a...

This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing....

Three-dimensional printed drug development is nowadays an active area in the pharmaceutical industry, where the search for an appropriate edible...

Although hot melt extrusion (HME) has been used in combination with fused deposition modelling (FDM) three-dimensional printing (3DP), suitable feedstock...

The aim of the current study was to investigate the dual effect of an amorphous solid dispersion generated by hot...

Hot Melt Extrusion is a well established technology used in ASDs. Besides the advantage of being a solvent free method...