Recent and Relevant Methodology in the Advancement of Solid Dispersion

Most of the promising drugs in development channels are poorly water-soluble drugs which limit formulation approaches, clinical application because of their low dissolution and bioavailability. And the major current challenges of the pharmaceutical industry are apropos strategies that improve the water solubility of drugs.

Solid dispersion has been considered one of the major evolutions in overcoming these issues with several successfully marketed products. Though solid dispersion has been outlined as an efficient drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the solubility and bioavailability of poorly water-soluble drugs.

Solid dispersion can be prepared by several methods such as solvent evaporation, melting, and supercritical fluid technology. This review intends to provide an updated overview of the recent trends over the past few years in solid dispersion preparation techniques and polymer used. Along with the various pharmaceutical strategies and future visions for the solubilization of poorly water-soluble drugs

Download the full article as a PDF here

Table 1: Summary related to overall techniques used recently with continually used polymer

SD Techniques	Drugs	Polymers	Ref.
Solvent evaporation	Dutasteride (DUT)	Microcrystalline cellulose	[16]
	Oleanolic acid (OA)	Leucine	[17]
	Efonidipine hydrochloride	HPMC-AS	[18]
	Sirolimus	Polyvinylpyrrolidone (PVP), Poloxamer 188 and Cremophore RH40	[19]
	Febuxostat (FB)	Polyvinylpyrrolidone (PVP K30) and poloxamer	[20]
	Ticagrelor	TPGS and Neusilin® US2	[21]
	Candesartan cilexetil (CC)	Tromethamine (Tris)	[22]
	Progesterone (PG)	Hydroxypropyl methylcellulose (HPMC), Hydroxypropyl methylcellulose acetate succinate (HPMCAS), Microcrystalline cellulose (MCC), Polyvinylpyrrolidone (PVP) and silica (SiO2)	[23]
	Andrographolide (ADG)	Silica (SiO2)	[24]
Hot melt extrusion	Fenofibrate (FNB)	PVP VA64	[28]
	Baicalein	Kollidon VA64 and Eudragit EPO	[29]
	Indomethacin (IND), Itraconazole (ITZ), and Griseofulvin (GSF)	Eudragit EPO, Eudragit L-100-55, Eudragit L-100, HPMCAS-LF, HPMCAS-MF, Pharmacoat 603, and Kollidon VA-64	[30]
	Indomethacin (IND)	Magnesium aluminium and lithium magnesium sodium silicates	[31]
	Carbamazepine (CBZ)	Eudragit EPO	[33]
	Osthole (OS)	Plasdone S-630, HPMC-E5, Eudragit EPO, and Soluplus	[34]
	Lacidipine	Soluplus and PVP VA64	[35]
	Triamterene	D-mannitol	[36]
Melt agglomeration	Diazepam	Polyethylene glycol (PEG) 3000 or Gelucire 50/13	[39]
	Lu-X	Rylo MG12, Gelucire 50/13, PEG 3000, or poloxamer 188	[41]
	Lumefantrine	Polyethylene glycol (PEG) 6000 or Poloxamer 188	[42]
Spray drying method	Indomethacin (IMC)	Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol	[44]
	Ibuprofen	Curcumin	[45]
	Candesartan cilexetil (CC)	PVPK30	[46]
	Pioglitazone	PVP K17, PVP K30, and HPMC E3	[47]
	Darunavir	Hydroxypropyl methylcellulose (HPMC), hydroxypropyl methylcellulose acetate succinate (HPMC AS) and polyvinylpyrrolidone K-30 (PVP)	[48]
	Tadalafil (TDL)	Glycyrrhizin	[49]
	Nisoldipine	Polyethylene glycol 4000 (PEG4000)	[50]
	Ketoprofen	vinyl-pyrrolidone based polymers	[51]
	Efavirenz	Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®)	[52]
Lyophilization	Efavirenz	Polyvinylpyrrolidone (PVP) K-30	[55]
	Famotidine	Soluplus® (SP)	[56]
	Prednisolone	Bovine serum albumin (BSA)	[57]
	Diclofenac sodium (DS)	Ethylcellulose (ECand chitosan (CS))	[58]
	Mebendazole (MBZ)	low-substituted hydroxypropylcellulose (L-HPC)	[59]
	Exemestane	Phospholipid/sodium deoxycholate	[60]
	Valsartan (VAL)	Polyethylene glycol 6000 (PEG6000) and hydroxypropylmethylcellulose	[61]
	Telmisartan	Polyvinylpyrrolidone (PVP) K30	[62]
	Tadalafil (Td)	HPMC, MC, PVP, PVP-VA, Kollicoat IR and Soluplus	[63]
Fusion method	Torcetrapib, itraconazole, and lopinavir	HPMCAS (L, M, and H), copovidone, Soluplus, PEG1500, Vitamin-E TPGS, Kolliphor EL, and Eudragit	[64]
	Spironolactone (SPL)	Polyethylene glycol 4000 (PEG 4000)	[65]
	Itraconazole	Eudragit E100	[66]
	Efavirenz	Polyethylene glycol8000, polyvinylpyrrolidone K30	[67]
	Thiocolchicoside (TCS)	Poloxamer-188	[69]
	Piroxicam	Solutol and Gelucire	[70]
	Atorvastatin calcium, cefuroxime axetil, clotrimazole, ketoconazole and metronidazole benzoate	Citric acid and sodium bicarbonate	[71]
	Atorvastatin	Polyvinyl pyrrolidone K30 (PVP), polyethylene glycol 6000 (PEG), Soluplus®, and chitosan	[73]
	Carvedilol (CARV)	Polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus® and Eudragit®	[74]
	Cefuroxime axetil (CA)	Silica	[77]
	Glyburide	Silica	[78]
	Bifendate	Poly (ethylene oxide) (PEO)	[79]
	Budesonide	Polyethylene glycol 4000 and 6000 and	[80]
	Cefixime trihydrate	Soluplus	[81]
	Furosemide	Crospovidone	[82]
Co- precipitation method	Quercetin (Que)	HPMCAS-HF, HPMCAS-MF and HPMCAS-LF	[83]
	Lumefantrine	HydroxypropylmethylcellulosePhthalate (HPMCP), hydroxypropylmethylcellulose acetate succinate (HPMCAS), poly (methacrylic acid-ethyl acrylate) (EL100) and cellulose acetate phthalate (CAP)	[86]
	Silymarin	HPMC E 15LV	[87]
	GDC-0810	Hydroxypropyl methylcellulose acetate succinate	[88]
Electrospinning	Ibuprofen (IBU)	HPMCAS and HPMCP-HP55	[92]
	Itraconazole (ITRA)	PVPVA64	[93]
	Spironolactone	Poly (vinylpyrrolidone-co-vinyl acetate)	[94]
	Itraconazole [ITR]	Polyvinylpyrrolidone-vinyl acetate	[95]
	Meloxicam	Eudragit E	[98]

Article information: Talla S, Wadher K, Umekar M, Lohiya R. Recent and Relevant Methodology in the Advancement of Solid Dispersion. JDDT [Internet]. 15Aug.2021 [cited 20Aug.2021];11(4-S):247-5. Available from: http://jddtonline.info/index.php/jddt/article/view/4963