Lipid Nanoparticles by Gattefossé

Lipid-based nanocarriers are promising tools to deliver APIs, including peptides, as their nanosize are in favour of transepithelial transport.

Solid Lipid Nanoparticles (SLN) are composed of lipids in solid state at room and body temperature, usually long chain triglycerides or partial glyceride, fatty acids, waxes, etc.

Precirol® ATO 5 is the preferred solid lipid carrier as it is digestible and exhibits a low melting point (around 50-55°C).

Nanostructured Lipid Carriers (NLC) contain both solid and liquid lipid at room and body temperature. The liquid lipids act as crystallization inhibitors of the solid lipid.

Capryol® 90 is the preferred liquid lipid excipient. Learn more on Lipid nanoparticles here

Gattefossé Publications on oral peptide delivery

A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations
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In Vitro Studies Indicate Promising Properties Of Solid Lipid Nanosuspensions for oral peptide delivery
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In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
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Lipid-based nanosuspensions for oral delivery of peptides, a critical review
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In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
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Lipid-based nanosuspensions for oral delivery of peptides, a critical review
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Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
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Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione
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Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery Systems
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