3D-printed magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with high strength and anti-tumor property
It is still a major challenge to remove tumor cells and fill bone defects after tumor resection. Combined with the 3D printing technology, the composite bioceramics scaffolds were fabricated with interconnected porous magnesium-doped wollastonite (CSi-Mg) scaffolds as the architecture and nano-hydroxyapatite (n-HA) as the surface. The influence of manufacturing process on the n-HA layer thickness and degradation performance, biological performance and anti-tumor performance of the composite scaffolds were investigated.
Highlights
- Customized magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with precise porous structures were fabricated by 3D printing and coating technique.
- Composite bioceramic scaffold with 15 μm coating thickness exhibited the highest mechanical properties.
- Nano-hydroxyapatite coating can effectively inhibite the proliferation of human osteosarcoma cells.
- Composite bioceramic scaffold had significantly enhanced osteogenic induction on Rat bone marrow stem cells.
The n-HA surface layer could effectively retard the degradation rate of CSi-Mg scaffolds and maintain high mechanical strength (over 90 MPa) after immersion in simulated body fluid for 3 weeks. Meanwhile, CSi-Mg/n-HA3 scaffold induced about 50 % of cell death for human osteosarcoma cells (MG-63) in vitro. CSi-Mg/n-HAx (x = 1, 3) scaffolds could improve the osteogenic performance of Rat BMSC. These findings demonstrate that the bioceramic composite scaffold with high strength, good osteogenic performance and anti-tumor performance is promising for the treatment of tissue injury after resection of osteosarcoma.
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Huifeng Shao, Zhuoluo Jing, Pengcheng Xia, Tao Zhang, Zhiheng Nian, Wanshun Liu, Jiahua Zhu, Youping Gong, Rougang Zhou, Yong He, Qingqiang Yao, 3D-printed magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with high strength and anti-tumor property, Materials & Design, Volume 225, 2023, 111464, ISSN 0264-1275, https://doi.org/10.1016/j.matdes.2022.111464.