Calcium phosphate microcapsules for paediatric drug delivery
This poster was presented by Galvita at EuPFI 2024 in Rotterdam
Introduction
Modern drug delivery needs to use novel multifunctional materials for developing medicinal products and new therapies.[1] Porous particles attract a lot of attention as promising drug delivery systems. Functions of porous particles are directly related to their surface properties, specific surface area, morphology, size and pore size distribution.[2] Our previous works have shown that porous functionalized calcium carbonate particles are a prototype material with several functions, i.e., they can be used as filler, disintegrant, tablet hardness enhancer, and encapsulation carrier at the same time. Besides the multifunctionality, it is a biocompatible, biodegradable, and non-toxic compound. On the other hand, we have identified some downsides, such as a limited encapsulation efficiency.[3-4] The latter results in drug depositions on the carrier’s surface, which leads to a loss of material multifunctionality as the physicochemical properties change.
Aim
Galvita provides a novel easy-loadable inorganic carrier material for paediatric drug delivery:
Template-InvertedParticles(TIP).
Concept
Clinical evaluation
Ivermectin loaded TIP
- Less inter subject variability in drug exposure[5]
- Excellent palatability and acceptability
- On going clinical studies: NCT05894057, NCT04716335 and NCT04508166
Drug loading
The cavity of TIP is loaded with API using a solvent evaporation approach. Loading is preferably performed using a fluidized bed equipment or a rotary evaporator.
Tablet characterization
Tensile strength & Disintegration time
Tablet features
Conclusion
- TIP isa monomaterial, consistingofpure tricalciumphosphatein theform ofhydroxyapatite
- Template InvertedParticles(TIP) microcapsulesarea platformtechnologyforthedevelopmentofODTs
- Drug-loadedTIP microcapsuleshavean excellentcompactability
- The maximal drugloadingcapacityis45% (v/v)
- TIP tabletsarewellacceptedin patients, particularlyin paediatrics, and havelessintersubjectvariabilityin drugexposure
See the full poster on “Calcium phosphate microcapsules” here
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Source: Galvita, J. Kost, J. Huwyler, M. Puchkov, poster “Calcium phosphate microcapsules”