Functionalized carbon nano onion as a novel drug delivery system for brain targeting
Pharmacologically active compounds having poor permeability through several physiological barriers often limits their application. New age therapeutics such as peptides or nucleic acid-based agents are promising but their targeted delivery to the brain is challenging through conventional drug delivery methods.
Highlights
Carbon nano onions are the least explored carbon nano particle as a drug carrier for cancer therapeutics.
Functionalized CNOs can be a good vehicle for targeted drug delivery to brain tissues.
Layered structure of CNO offers more surface area for drug intercalation and controlled release based on target tissue microenvironment.
Nasal drug delivery increase bioavailability of the therapeutic agent and decrease the dose.
The objective of using carbon nano onions is to develop potential nanoscale carriers for effective diagnosis and targeted therapies. Pharmacokinetic and pharmacodynamic profiles of such nanocarriers can also be controlled, enhancing the drug concentration at target sites.
This review critically evaluates the current status of the carbon nano onion mediated targeted delivery of the drugs through nasal pathway bypassing the biological barriers. This intranasal drug delivery system can escape the first-pass metabolism, increases the bioavailability of the drug to the targeted area reduces the dose of chemotherapeutic reagents having serious side effects.
Article information: R. Majumder, T. Pal, A. Basumallick, Chitrangada Das Mukhopadhyay. Functionalized carbon nano onion as a novel drug delivery system for brain targeting, Journal of Drug Delivery Science and Technology, Volume 63, 2021. https://doi.org/10.1016/j.jddst.2021.102414.