Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds

Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or treatment of numerous chronic diseases have been studied, but a major drawback is still the low bioavailability of these compounds, as well as their instability towards pH, temperature, and light in some cases. Nanotechnology has emerged as an alternative to overcome these limitations, and the use of lipidic encapsulation systems is a promising technique to achieve an efficient drug delivery, protecting molecules from external factors and improving their bioavailability. In this review, solid lipid nanoparticles and nanostructured lipid carriers are highlighted as an important tool for the improvement of the bioavailability and stability of natural phenolic compounds, including their preparation methods and functionalization approaches and the discussion of several applications for putative use in cosmetic and pharmacologic products.

Download the full publication here: Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds

or continue reading here: Borges, A.; de Freitas, V.; Mateus, N.; Fernandes, I.; Oliveira, J. Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds. Antioxidants 2020, 9, 998.

Examples of solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) applications, lipids, and surfactants used in their preparation (from this publication)

Lipid NanoparticleIncorporated MoleculeLipidsSurfactantsApplication
SLNVitamin EPrecirol ATO 5Tween 80Skin applications
SLNQuercetinGlyceryl monostearate (GMS)Tween 80 and polyethylene glycol (PEG) 400Food applications
SLNBaicalenTripalmitin, Gelucire 48/9, and Gelucire 62/5Poloxamer 188Treatment of ischemic stroke
SLNApomorphine hydrochlorideTripalmitin, hydrogenated soybean phosphatidylcholine (HSPC), glyceryl monostearate (GMS), and polyethylene glycol monostearate (PMS)Pluronic F68, L-ascorbic acidTreatment of Parkinson’s disease
SLNTetandrineCompritol 888 ATOMyrj 52Treatment of ocular diseases
SLNOfloxacinPalmitic acidPolyvinyl alcohol (PVA)Improvement of pharmacological activity 
NLCCurcuminPrecirol ATO 5 and Miglyol 812Lutrol F68 and Tween 80Intraperitoneal administration
NLCCalcipotriol, methotrexatePrecirol ATO 5, squalene mixture, Myverol 18-04KPluronic F68Treatment of psoriasis
NLCPaclitaxelGlyceryl monostearate (GMS), soya lecithin, soybean oilHexadecyl trimethyl ammonium bromide (CTAB)Cancer targeting
NLCmTHPC (commercial formulation Foscan)Soybean oil and Suppocire NBLipoid S75, Myrj S40Photodynamic therapy 
NLCMediterranean essential oilsLabrafil, Softisan 100Kolliphor RH40, Tween 80Treatment of Candida skin infections

Keywords: solid lipid nanoparticles; nanostructured lipid carriers; phenolic compounds; bioactivity; chemical stabilization

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