Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: formulation, miscibility, in vitro and in vivo studies

Chart of how chitosan works for ocular drug delivery — Chitosan films for ocular drug delivery systems

Polymeric films were prepared based on chitosan and its blends with poly(2-ethyl-2-oxazoline) by casting from aqueous solutions. These materials were characterised using a number of physicochemical techniques, including Fourier-transform infrared spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, wide angle x-ray diffraction, tensile testing and scanning electron microscopy.

All these studies indicate that there is a weak intermacromolecular hydrogen bonding between these polymers, which facilitates their complete miscibility in solid state. These films were formulated with sodium fluorescein as a model drug and were evaluated for their potential application in ocular drug delivery both in vitro and in vivo. It was established that the films are biocompatible and mucoadhesive; they are capable of providing a sustained drug release when administered topically on the cornea.

Sustainable Alternatives to Petroleum-Derived Excipients in Pharmaceutical Oil-in-Water Creams

Investigating the Effectiveness of Different Porous Nanoparticles as Drug Carriers for Retaining the Photostability of Pinosylvin Derivative

Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches Based on Poly(Lactic Acid) and Moisture-Indicating Silica

Article Information: Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: formulation, miscibility, in vitro and in vivo studies – Guzel K. Abilova, Daulet B. Kaldybekov, Elvira K. Ozhmukhametova, Aisulu Zh. Saimova, Diara S. Kazybayeva, Galiya S. Irmukhametova, Vitaliy V. Khutoryanski. ScienceDirect 2019

excipients