Assessment of a Once-Daily Controlled-Release Ibuprofen Matrix Tablets Prepared Using Eudragit®E100/Carbopol®971P NF Polymers and Their Salts Combinations.
Introduction
Hydrophilic polymers that swell or dissolve in aqueous media can have the potential to prepare controlled/sustained dosage forms for weakly acidic, poorly soluble drugs.
Objective
The main objective of this study is to utilize Eudragit®E100 (EE) and Carbopol®971P NF (Cp) polymers and their salt forms in the preparation of a once-daily controlled-release matrix tablet for model drug, Ibuprofen (IB).
Methods
Combinations of the polymers in their base forms (EE)/(Cp) or their salt forms (EEHCl/CpNa) were compressed with (IB) into single layer matrix tablets, or otherwise into bilayer tablets. Dissolution profiles were constructed using three different consecutive stages (pH 1.2, 4.8, and 6.8).
Result
It was found that the incorporation of (EEHCl) modified the release rates of (IB) from (Cp) based matrix tablets. However, a major enhancement of (IB) release rates occurred when the polymers were combined in their salt forms at a 1:1 ratio by weight. In addition, a bilayer tablet was prepared wherein a relatively rapidly disintegrating layer composed of polymers salts (EEHCl and CpNa), and a second layer containing only (Cp) polymer in its base form at a 1:2 weight ratio possessed excellent release properties, and mechanical strengths.
Conclusion
It was concluded that the prepared bilayer tablet could be of promise use in controlling the release rates of (IB) in an extended manner to allow once-daily administration with an improved pH-independent release behavior
Wasfy Obeidat* and Mohammad Mohammad Al Natour, “Assessment of a Once-Daily Controlled-Release Ibuprofen Matrix Tablets Prepared Using Eudragit®E100/Carbopol®971P NF Polymers and Their Salts Combinations. ”, Current Drug Delivery 2021;
https://doi.org/10.2174/1567201818999210625100126