Cyclodextrins-modified metallic nanoparticles for effective cancer therapy

Cancer, a disease of unknown origin is the second most common reason of death worldwide after heart attacks and therefore is a major threat to human beings. Currently, chemotherapy is the only approach for delivering anti-cancer drugs but shows severe systemic toxicities such as alopecia, loss of appetite, anemia, gastric irritation, neurotoxicity and nephrotoxicity. Additionally, chemotherapeutics fails to achieve the expected therapeutic outcome due to their limited solubility, in-vivo instability and lack of targeting efficiency.

Highlights

Metallic nanocarriers are used in delivering drugs at targeted site effectively.

Cyclodextrins are structurally compatible for encapsulating anti-cancer drugs.

Combination of cyclodextrin and metallic nanocarriers provide a novel approach for cancer treatment.

These nanocarriers shows better therapeutic value than conventional therapy.

Encapsulating drugs in metallic nanoparticles like gold, silver and metal oxides (magnetic) help to overcome limitations of chemotherapy and transports anti-cancer drugs effectively at the targeted site due to the advantages such as optimal size, surface morphology, higher conductivity and in-vivo stability. Moreover, these metals can be triggered externally using NIR radiations or magnetic field thereby improving the drug release kinetics. Some frequently used chemotherapeutic agents such as doxorubicin, paclitaxel, methotrexate, etc. degrade rapidly due to their hydrophobic nature and show in-vivo instability.

Cyclodextrin offers structural compatibility for encapsulating such hydrophobic drugs and improves their loading capacity, solubility and stability without showing any systemic toxicities. Therefore, researchers designed cyclodextrin-complexed metallic nanoparticles as a novel platform to overcome pitfalls of conventional chemotherapy like gastric irritation, hair loss, neurotoxicity, etc. This review article provides detail insight of metallic nanocarriers containing cyclodextrin-encapsulated anti-cancer agents for effective cancer therapy. It can be concluded that this novel approach holds a great potential for clinical application in cancer diagnosis, treatment with minimum toxicity and maximum efficacy.

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Article information: Sahil Gandhi, Pravin Shende, Cyclodextrins-modified metallic nanoparticles for effective cancer therapy, Journal of Controlled Release, Volume 339, 2021. https://doi.org/10.1016/j.jconrel.2021.09.025.