Direct Compression Granules for more than just Tableting

With DC granules, Dr. Paul Lohmann® manufactures a product line that is ideally suited for direct tableting for pharmaceutical applications and food supplements.

The Direct Compression Granules product line by Dr. Paul Lohmann^® covers Calcium, Magnesium, Iron and Zinc Salts offering lots of application benefits.

The granulation process enlarges the particle size by converting fine or coarse powders into physically strong and larger granules with uniform shape, good flow property as well as good compression characteristics.

Granules are formed by adding a liquid solution (water with or without binding agent) to powders. Binding agents of the product line are maltodextrin, starch, PVP, citric acid and gum arabic. From a production point of view, DC (direct compressible) grades offer excellent tableting properties. Granulated DC grades solve challenges during the tableting process due to the physical modification. Tablet manufacturers usually use wet granulation of powders prior to the tableting process to improve the compactability and flowability of a tablet formulation. The use of directly compressable granulated Minerals for the tableting process eliminates the need of an in-house granulation process, and offers vast advantages in terms of production capability and cost.

Benefits of DC Granules

• Excellent tableting properties
• Improved flowability
• Decrease dust generation
• Lower costs, faster processing

In wet granulation, physically solid and larger granules are formed from fine or coarse powders by adding a granulating liquid (water with or without binder). Proven binders for granules with good flowability and good printing properties are maltodextrin (M), corn starch (S), polyvinylpyrrolidone (PVP) (P), citric acid (CA) and gum arabic (GA).

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Modification of DC Granules by usage of micronized raw materials offers further advantages

• Combination of micronization and granulation
• Neutral taste
• No sandiness, great mouthfeel
• Good flowability
• Good compression properties

Recommended for the following applications / dosage forms

• Tablets
• Chewing tablets
• Chewing gums
• Effervescent tablets
• Coated tablets
• Sachets
• Capsules

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Source: Dr. Paul Lohmann, website Granules for Direct Compression

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