This review gives a nice overview on Multiple Unit Dosage Forms vs. Single Unit Dosage forms and a special focus on mini-tablets.

Abstract

Mini tablets are solid dosage forms with a diameter ≤ 3 mm and separated into subunits of conventional tablets. Production methods are similar to standard tablets, but the only difference is the use of multiple punches. They have advantageous for use in patients suffering from swallowing difficulty and receiving multiple drug treatment. They provide a more effective treatment by reducing the fluctuation in the drug’s release profile. At the same time, different release systems can be used together. In addition, mini tablets have a number of advantages over single unit dosage forms, and in recent years the prominence continues to increase. In the light of this information, the advantages and disadvantages of mini tablets, production equipment, formulation designs, different emission characteristics and evaluation criteria are emphasized in this compilation.