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The purpose of present investigation was to develop and evaluate floating drug delivery system of an antimigraine drug (sumatriptan), the floating tablets of Sumatriptan were prepared by using HPMC K15M, HPMCE15LV, Carbopol 940 polymers. The precompression and post compression evaluation were performed as per pharmacopoeial standards. The tablets were prepared by direct compression method. Dissolution measurements were carried out in a (USP) dissolution testing apparatus II. Compatibility study was performed by FTIR. The compatibility study of the prepared Sumatriptan floating tablets confirms that there is no interaction between the drug and polymers used. The release data were subjected to different models in order to evaluate their release kinetics and mechanisms. The drug release kinetics was observed by Non-fickian diffusion mechanism. The floating lag time were found to be significantly increased with the increasing concentration of the polymers. After the dissolution study of prepared Sumatriptan floating tablet it was concluded that the formulation with HPMC E15 LV shows better sustained release effect. The release kinetic data implies that the release mechanism of all the formulations was Non-fickian. The developed floating tablets of Sumatriptan may be used to prolong drug release for at least 12h, thereby improving the bioavaibility and patient compliance.
Keywords: Sumatriptan, gastroretentive, floating drug delivery, sustained release.
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Dr. R. Srinivasan1, Sk. Shakir Ahmad1*, D. SK. Sarma1, D. Rajesh Kumar1, Dr. K. Ravi Kumar2, V. Mahesh Swami1
1Siddhartha Institute of Pharmaceutical Sciences, Jonnalagadda, Narsaraopet, Guntur, A.P, India
2Assosciate Professor, Hindu college of Pharmacy, Guntur, Andhra Pradesh, India
Received 28 September 2014, Accepted 28 November 2014, Available Online 10 February 2015
Int. J. Med. Pharm. Res., 2015, 3(1): 937-941
