GASIL® Mesoporous Silicas – Elevating Pharmaceutical and Nutraceutical Excellence

Elevating Pharmaceutical and Nutraceutical
Excellence with Gasil® Mesoporous Silica

INTRODUCTION

In the pharmaceuticals and nutraceuticals sector, the quest for superior solid formulations is unending. Achieving them is a complex challenge. Formulations are mixtures of powders of different granulometry and hygroscopicity and liquids with different viscosity and hydrophilicity. Synthetic and natural ingredients and excipients like polymers are also often sensitive to moisture. Those that are liquid will render formulations sticky and affect their processability and require accurate dosing that can only be delivered in a dry form. The use of flow aids is essential to ensure solid actives flow well for tablet compaction. Many APIs have low solubility and require amorphization to enhance their solubility and effectiveness in vivo. Gasil® mesoporous silica gels provide solutions to many of the problems encountered in solid pharmaceutical and nutraceutical formulations. They are multi-functional excipients that:

• Improve moisture stability
• Serve as glidants at any relative humidity
• Improve tablet strength and friability at lower compression forces
• Enhance tablet coatings by providing antitacking properties through microroughness
• Increase the amorphous stability of APIs and polymer based solid dispersions
• Help optimising disintegration vs strength.

Manufacturing Process

Gasil® mesoporous silicas are manufactured from sodium silicate and sulfuric acid. Further steps in the process are used to improve purity, tailor the porosity and control the particle size distribution. This generates powders with unique combinations of physical properties and related benefits in the pharmaceutical and nutraceutical formulations.

Gasil® Range of Excipients for Pharmaceutical and Nutraceutical Formulas

PQ manufactures mesoporous silicas for pharmaceutical applications. The table below shows their physical properties:

Physical Properties and Internal Porosity

Gasil® mesoporous silicas boast superior physical properties that contribute to the varied benefit of their use in formulations. High internal porosity, as measured by nitrogen adsorption, ensures a high moisture adsorption capacity and controlled API interactions. Gasil® silicas display high water adsorption capacity. Gasil® GM2FP shows high absorptive capacity at low relative humidities for API moisture protection and Gasil® HP33CP and Gasil® HP54CP have high absorptive capacity at higher relative humidity, which can be used effectively in moisture activated dry granulation (MAGD). Relatively low surface area products Gasil® HP54CP and Gasil® HP33CP aid tablet compaction properties, enhancing friability, hardness and disintegration.

Gasil® Mesoporous silicas excel within many pharmaceutical applications, which are detailed in the table below.

See the full brochure on GASIL® Mesoporous Silicas here

(click the picture to download the brochure)

Source: PQ, brochure GASIL® Mesoporous Silicas

You are interested in a sample? Just fill in the form: