A Shrewd Ingenious Approach of Oral Drug Delivery of Insulin for the Amelioration of Diabetic Patients with Better Therapeutic Outcomes
![Fig. 1. The theoretic advantage of oral insulin versus subcutaneous (SC) injection [8]](https://www.pharmaexcipients.com/wp-content/uploads/2023/10/Fig.-1.-The-theoretic-advantage-of-oral-insulin-versus-subcutaneous-SC-injection-8.jpg)
Since 1922, insulin has saved the lives of countless people. However, the difficulties of subcutaneous administration, the need for frequent glucose self-monitoring, and the non-physiological action profiles of insulin prompted many medical professionals and patients to ask fornon-injectable insulin delivery methods.
Alternative administration techniques without the need for an injection are widely desired. Since it is simple for patients and doesn’t involve injection, the oral route is the preferred way to provide medication. The gastrointestinal stability of protein therapeutics is one of several major obstacles to the effective development of oral protein medication formulations.
An oral formulation for a protein and peptide medication must maintain the medication’s structural integrity, guard against proteolysis, and enable bloodstream absorption. To satisfy these needs, a number of strategies for oral protein administration have been suggested. When assessing the potential of insulin-loaded nanoparticles, toxicity is a crucial element to take into account. Nanoparticles must be checked to make sure they don’t have any negative impacts or even harm the intestinal epithelium because they are designed to interact with 527 Oral Insulin Delivery.
Oral insulin delivery has been an interesting and promising research field that promises to revolutionize the way diabetes mellitus is treated. Overall, the success of oral insulin hinges on the ability to produce insulin both effectively in a price-conscious pharmaceutical market and in adequate amounts for oral delivery. It is evident that more effort needs to be done to bring the first insulin oral delivery system to the market. Pharmaceutical companies are leading the charge in creating a system to give insulin orally. Successfully addressing the problems will usher in a new era of diabetes care.
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Excipients mentioned in the paper: PEG-grafted polymers,chitosan, lectin, sodium alginate, cellulose derivatives, Poly(methacrylicacid-gethylene glycol), poly(methacrylicacid-coN-vinyl pyrrolidone), poly((methacrylic acidco-N-vinyl pyrrolidone) – g-ethylene glycol),poly (itaconic acid-co-N-vinyl pyrrolidone.
Asian Journal of Research and Reports in Endocrinology, Volume 6, Issue 1, Page 141-150, 2023; Article no.AJRRE.104285, A Shrewd Ingenious Approach of Oral Drug Delivery of Insulin for the Amelioration of Diabetic Patients with Better Therapeutic Outcomes, Gannoji Sainath Chary, Basani Pavithra Reddy, Rasuri Charishma, Asra Tabassum and Samreen Afroz, Received: 30/05/2023, Accepted: 04/08/2023, Published: 21/08/2023
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