Additive Manufacturing in Pharmaceuticals – Part 2

Additive Manufacturing in Pharmaceuticals

See the new book, edited by Dr. Subham Banerjee, Ph.D., Associate Professor in the Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Guwahati, Assam, India.

Description: This book presents the different 3D/4D printing technological applications of Additive Manufacturing (AM) in Pharmaceutical Sciences. The initial chapter provides the historical perspective and current scenario of AM in pharmaceuticals. The book further discusses about different 3D printing platform technologies such as FDM, SLA, SLS, SSE, Ink-jet & binder jet principles & applications in developing advanced drug delivery systems. It also covers the methodology, materials for AM and important parameters associated with these platform technologies. The book highlights the progress and practical applications of 4D-printing technology in healthcare & pharmaceuticals fraternity as well including the essence of bioprinting in pharmaceuticals. Finally, the book reviews the regulatory guidelines, perspectives, and integration of Artificial Intelligence (AI)/Machine learning (ML) in pharmaceutical AM. This book is indeed a valuable resource for students, researchers/scholars, young start-ups/entrepreneurs, and pharmaceutical professionals by providing thorough detailing about AM in Pharmaceuticals.

Chapter 5

Semi-Solid Extrusion (SSE) in Pharmaceuticals

Semi-solid extrusion (SSE) is an extrusion-based 3D printing technique, widely employed in food printing and bioprinting. In pharmaceutics, SSE is becoming the most explored technique to obtain solid dosage forms with specific characteristics, such as chewable, fast-dissolving or gastro-floating tablets, polypills, oral and topical films, and rectal suppositories, among others. The advantages of SSE include a low work temperature, with less risk of drug instability, and the availability of a broad range of excipients (e.g., natural or synthetic polymers, lipids and food additives) as feedstock materials to obtain gels or pastes in the 3D printing process. However, the properties of the dosage forms can be impacted by formulation-related factors, like the semi-solid rheological behaviour, the size of the dispersed materials, and the geometrical shape of the dosage form, as well as the parameters of the printing process, such as printing speed, infill pattern and number of layers. Due to this versatility, SSE has become a powerful tool to produce innovative dosage forms with clinical relevance for specific groups, including paediatric, geriatric and veterinary populations, as personalised medicines.

See the chapter

Funk, N.L., Leão, J., de Oliveira, T.V., Beck, R.C.R. (2023). Semi-Solid Extrusion (SSE) in Pharmaceuticals. In: Banerjee, S. (eds) Additive Manufacturing in Pharmaceuticals. Springer, Singapore. https://doi.org/10.1007/978-981-99-2404-2_5

Chapter 7

4D Printing: The Next Dimension of Healthcare in Cancer Research

Four-dimensional (4D) printing has received growing interests in healthcare with advancements in individualized dynamic constructs, including controllable shape transformation or triggerable function upon exposure to stimuli. It is emerging as a technology that can play a critical role in aiding cancer treatments, with potential abilities of shape, function, or property changes, facilitating personalized medicine for localized cancer treatments. Here, smart materials used in 4D printed approaches are presented to explore their purpose and utilities in aiding cancer therapeutic approaches. To guide 4D printed materials in various perspectives, recently reported progress on applications of using 3D and 4D printing in aiding cancer treatments and tools, such as hyperthermia, drug delivery systems for chemotherapy, and pharmaceutical models of cancer management, is discussed. Lastly, the challenges and future visions of 4D printing research are proposed.

See the chapter

Chinnakorn, A., Nuansing, W., Kouzani, A.Z., Bodaghi, M., Zolfagharian, A. (2023). 4D Printing: The Next Dimension of Healthcare in Cancer Research. In: Banerjee, S. (eds) Additive Manufacturing in Pharmaceuticals. Springer, Singapore. https://doi.org/10.1007/978-981-99-2404-2_7

See the full book here

Dr. Subham Banerjee, Ph.D., Additive Manufacturing in Pharmaceuticals, Hardcover ISBN 978-981-99-2403-5, Published: 14 September 2023, eBook ISBN 978-981-99-2404-2, Published: 13 September 2023, DOI https://doi.org/10.1007/978-981-99-2404-2

There will be to additional articles here soon with the remaining book chapter contents:

• See Part 1
• See Part 3