Monosodium Glutamate: The Ultimate Cell Culture Booster for Your Bioproduction Processes
Sodium L-glutamate, better known as Monosodium glutamate (MSG) by Dr. Paul Lohmann® , has emerged as a crucial component in bioproduction processes, particularly in the cultivation of certain microorganisms, significantly enhancing biopharmaceutical processes.
Applications in growth media
Cell growth:
MSG is an essential nutrient in cell culture, particularly in the production of mammalian cell-derived biopharmaceuticals. MSG ensures stable and efficient growth conditions as an important amino acid for mammalian cell metabolism. Additionally, it helps to stabilize the pH balance of the culture medium, which is vital for cell health.
Protein expression:
In recombinant protein expression systems, where microorganisms are genetically engineered to produce specific proteins of interest, the addition of MSG to the growth medium enhances protein expression. The availability of nitrogen and carbon from Monosodium glutamate serve as a nitrogen and carbon source supporting optimal conditions for protein synthesis and folding, potentially improving the yield and quality of the recombinant protein.
Excipient
Stabilizer:
MSG is used as stabilizer in vaccines and other pharmaceutical formulations, protecting active pharmaceutical ingredients from degradation, increasing the shelf life and efficacy of products.
Enhancer:
MSG can improve the solubility and bioavailabilty of active ingredients, facilitating better drug delivery and absorption in the body.
Taste improvement:
MSG is used in oral medications to improve taste and mask unpleasant flavors, which increases patient acceptance and compliance.
Research relevance and quality requirements
Monosodium glutamate is also of great importance in research. It plays a key role in the study of cellular metabolic pathways, particularly in the glutamine-glutamate cycle, which is of central importance in both normal and cancer cells. In neuroscience, glutamate is a major neurotransmitter in the brain, important for development, cognition, learning and memory. Its study contributes to the development of new treatments for neurological diseases such as epilepsy, amyotrophic lateral sclerosis or Parkinson´s disease.
For biopharmaceutical applications, high purity of MSG is required to avoid impurities that could affect the quality of cell cultures or products. Therefore, our Monosodium glutamate is produced under strict GMP standards and our DPL Biopharm grade, including microbiological limits and low in endotoxin quality, ensures exceptional results for your applications.
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Source: Dr. Paul Lohmann, website Monosodium Glutamate