Hollow mesoporous silica nanoparticles-loaded ion-crosslinked bilayer films with excellent mechanical properties and high bioavailability for buccal delivery
Mucoadhesive buccal films (MBFs) become the most promising buccal mucosal delivery system duo to its advantageous properties, including simple preparation technique and better patient compliance. The mechanical properties and mucoadhesion of MBFs are crucial in their successful performance as well as manufacturing and administration. In this study, we prepared hollow mesoporous silica nanoparticles-loaded ion-crosslinked bilayer films ([email protected]) using carboxymethyl chitosan (CCS) and polyvinyl alcohol (PVA) for buccal delivery of furosemide (FSM). The FSM-loaded hollow mesoporous silica nanoparticles ([email protected]) were firstly characterized by SEM, TEM, and nitrogen adsorption/desorption. Then, we constructed an ion-crosslinked network using CCS and PVA employed with the solution casting method, and sodium tripolyphosphate (TPP) was used as a hydrogen bond crosslinking agent. The formulation was optimized through Box-Behnken design, where the impact of the proportion of the ingredients on the quality of the films was evaluated entirely. Herein, folding endurance, swelling, tensile strength, and adhesion force were selected as response variables.
Highlight
- • Hollow mesoporous silica nanoparticles-loaded ion-crosslinked bilayer films
([email protected]) were prepared for buccal delivery of furosemide.- • [email protected] films exhibited outstanding mechanical properties and excellent bioadhesion.
- • [email protected] films achieved great acceptance among volunteers.
- • In pharmacokinetic study with golden hamster models, the relative bioavailability was increased by 191.54%.
Morphology, mechanical, spectroscopic, thermal, and safety of [email protected] films were also investigated. The release and permeability behaviors of [email protected] films were evaluated by in vitro drug release, across isolated porcine buccal and TR146 cell model. The [email protected] films showed outstanding mechanical properties, suitable bioadhesion, high drug loading, significant sustained-release properties, and improved permeability. In pharmacokinetic study with golden hamster models, the relative bioavailability was increased by 191.54%, and the absolute bioavailability was 82.20%. In summary, this study provides evidence that this innovative [email protected] films could be a promising and industrialized buccal drug delivery system.
Shuangqing Wang, Lin Jiang, Saige Meng, Chao Liu, Huanhui Wang, Zhonggao Gao, Jianpeng Guo,
Hollow mesoporous silica nanoparticles-loaded ion-crosslinked bilayer films with excellent mechanical properties and high bioavailability for buccal delivery,
International Journal of Pharmaceutics, Volume 624, 2022, 122056, ISSN 0378-5173,
https://doi.org/10.1016/j.ijpharm.2022.122056.