Formulation and evaluation of ocular self-nanoemulsifying drug delivery system of brimonidine tartrate

The aim of the current study was to develop an ocular Self-nanoemulsifying drug delivery system (SNEDDS) loaded with Brimonidine tartrate (BRT) and evaluate its ex-vivo permeability. SNEDDS loaded with BRT were prepared by low energy method. Physicochemical properties, drug release, ex-vivo permeation, and toxicity studies were investigated. The BRT-loaded SNEDDS formulation was composed of Capmul MCM (Oil), Tween 80 (Surfactant), and Transcutol HP (Co-surfactant) and was optimized by Box-Behnken design. Optimized SNEDDS loaded with BRT had a droplet size of 118.3 nm, a PDI of 0.251, a pH of 6.34 ± 0.31, an osmolarity of 329 mosm/L after reconstitution with NaCl, and a viscosity was found to be 12.39 ± 2.31 cP. The optimized SNEDDS loaded with BRT had excellent stability in the shelving period. The apparent permeability coefficient of optimized SNEDDS was found to be (7.078 ± 0.218 × 10⁻⁶ cm/s) when compared to the marketed formulation with (3.127 ± 0.173 × 10⁻⁶ cm/s). These results suggest that Brimonidine tartrate-loaded SNEDDS can be used as a promising nanocarrier for ocular drug delivery.

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Bala Vikash, Shashi, Narendra Kumar Pandey, Bimlesh Kumar, Sheetu Wadhwa, Umesh Goutam, Aftab Alam, Faisal Al-Otaibi, Pramila Chaubey, Gulam Mustafa, Gaurav Gupta, Kamal Dua, Sachin Kumar Singh, Formulation and evaluation of ocular self-nanoemulsifying drug delivery system of brimonidine tartrate, Journal of Drug Delivery Science and Technology, Volume 81, 2023, 104226, ISSN 1773-2247,
https://doi.org/10.1016/j.jddst.2023.104226.