Mitigating Particle Formation During Ultrafiltration/Diafiltration of Biologics with KLEPTOSE® HPβCD (Hydroxypropyl Beta-Cyclodextrin)
INTRODUCTION
Ultrafiltration/diafiltration (UF/DF) is an integral part of every biotherapeutic downstream process. A typical UF/DF process requires several passes through the pump and the membrane cassette, often taking several hours for completion. During this time, proteins are exposed to several physical stresses, forming higher order…