CDMO for PolyAmino Acids – PMC Isochem
Why a PAA based delivery technology?
Growing interest for advanced biomedicines!
Polyamino acids (PAAs)-based materials have gained much attention in the field of biomedicine as they demonstrate remarkable biocompatibility and biodegradability due to the nature of the building amino acid monomers. Production of polypeptides via ring opening polymerization of amino acid N-Carboxyahydride monomers yields narrow polydispersity, minimal side product formation, high reproducibility, versatile architectures and precise functionalization of the polypeptide backbone.
Engineering polypeptide architectures in order to mimic nature and cross biological barriers in a given pathology for drug delivery is nowadays being exploited in different preclinical studies and clinical trials. O. Zagorodko et al, Macromol. Biosci. 2017, 17, 1600316.
PAA GMP Manufacturing
FDA Audited manufacturing plants
PMC Isochem: a unique integrated solution
- Highly talented & multidisciplinary R&D team with Academic connections.
- Fully equipped infrastructures and network to access cutting-edge technologies.
- Custom PAA supported by integrated NCA supply and development
PAA Development & CMC
- PAA as Starting materials, Excipients or APIs.
- Integrated high quality and unique NCA catalogue
- Process development.
- Analytical development.
- Full QA/Regulatory support for clinical stage.
- CMC Dossier
Download the full PAA based delivery brochure as a PDF here
Number One in manufacture of NCA
25 years / 60 monomers
Business
- Lean approach to provide a faster, cheaper and better solution to allow you to save time, costs and to limit risks.
- Flexible and creative business development team.
Precinical and clinical batches
- 40 years experience in large scale GMP.
- Production of NCA and Custom of Manufacturing of PAA.
- PAA From Kilolab to full scale production.
- US & EU audited manufacturing facilities
- Regulatory experience (DMF, CMC file, …).
- 3 production Sites (France).
Market
- Commercial batches of Starting Materials, Excipients and APIs.
- QA and regulatory affairs to cover Product/Project lifecycle management.
Download the full PAA based delivery brochure as a PDF here
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