Printing of small molecular medicines from the vapor phase

Nanotechnology — Trehalose Conjugated, Catechin Loaded Polylactide Nanoparticle

There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles.

The printed films exhibit similar crystallographic order and chemistry as the original powders; controlled, order-of-magnitude enhancements of dissolution rate are observed relative to powder-form particles. In vitro treatment of breast and ovarian cancer cell cultures in aqueous media by tamoxifen and BAY 11-7082 films shows similar behavior to drugs pre-dissolved in dimethyl sulfoxide. The demonstrated precise printing of medicines as films, without the use of solvents, can accelerate drug screening and enable continuous manufacturing, while enhancing dosage accuracy.

Preparation, Characterization, and Evaluation of a Novel Co-Processed Excipient as a Directly Compressible Vehicle in Antihypertensive Tablet Formulation

Benefits of an Optimal Tabletability DC Mannitol on Compression Setting Parameters

Amorphous – state Characterization and Dissolution Behaviour of Efavirenz – Tocopheryl Polyethylene Glycol Succinate (TPGS)-1000 Solid Dispersions

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Article Information: Olga Shalev, Shreya Raghavan, J. Maxwell Mazzara, Nancy Senabulya, Patrick D. Sinko, Elyse Fleck, Christopher Rockwell, Nicholas Simopoulos, Christina M. Jones, Anna Schwendeman, Geeta Mehta, Roy Clarke, Gregory E. Amidon & Max Shtein; Nature Communications 8, Article number: 711 (2017)

excipients