All4Nutra
Stable and efficient semisolid preparations with optimal skin-feel have become the desirable standard in topical and
transdermal drug delivery. Lubrizol Life Science Health (LLS Health) has long-standing experience with semisolids,
offering rheology-modifying, emulsifying and bioadhesive excipients.
Our Carbopol® polymers, Pemulen™ polymers, and Noveon® polycarbophil have been used extensively for more than fifty years in both prescription and over-the-counter topical drug products.
Topical Applications – All polymers listed in the chart below are suitable for use in topical applications and are present
in commercialized topical products. Topical applications can include creams, lotions, gels, and ointments for dermal,
vaginal, and rectal use, among others.
Enabling innovation through our multifunctional excipients, which are:
- Ideal for imparting rheology control in topical formulations
- Highly efficient thickeners and gel formers at low usage levels in aqueous, hydroalcoholic, and anhydrous systems
Typical Usage Levels of LLS Health Polymers in Topical Applications
- Able to provide stable, uniform emulsions and suspensions
- Excellent bioadhesive polymers for improving the bioavailability of some active ingredients
- Compatible with acidic, basic, and neutral drugs
- Thermally stable, allowing for versatility in manufacturing and final product sterilization
- Optimal for providing enhanced aesthetics and feel for the creation of non-greasy creams, exceptionally clear gels, and other semisolid formulations
Additional FDA IID Ingredients – LLS Health also offers an array of additional inactive ingredients for semi-solid topicals, such as humectants, emollients, emulsifiers, and surfactant thickeners. The below ingredients
are featured on the FDA’s Inactive Ingredient Database (IID). Please visit our website for more information.
*US Food and Drug Administration’s Inactive Ingredient Database.
**The IID is updated quarterly. For the most current information, please refer to the FDA Inactive Ingredient Database.
***Renewable Carbon Index (RCI) is calculated under ISO 16128. RCI = 1.00 meets the definition of natural under the ISO standard. RCI > 0.50 meets the definition of derived-natural.
See the full brochure on “Topical Drug Delivery” here
(click the picture to download the brochure)
Source: Lubrizol technical brochure “Topical Drug Delivery“
Do you need more information or a sample of Lubrizol excipients?
