Compressol™ ProTab in Diosmin Applications

FROM CHALLENGE TO TRIUMPH

Formulating high‑dose, poorly compressible APIs like Diosmin is challenging due to their fine particle size, irregular shape, and inherently poor flow. These material limitations can result in weight variability, capping, lamination, and inconsistent hardness at scale. Conventional excipients rarely provide the flow or strength needed to manage these issues. Compressol ProTab, a next‑generation co‑processed excipient, offers a strong solution with excellent flow, enhanced compactibility, and low‑moisture behavior. Its optimized performance improves powder handling, die filling, and tablet robustness—making it especially effective for demanding formulations such as micronized Diosmin.

THE CHALLENGES

• Flowability: Many APIs do not flow uniformly, causing die filling variability and weight inconsistencies.
• Compressibility: Many APIs fail to form strong tablets under standard compression forces. Moisture
• Sensitivity: Can contribute to stability issues.
• Hardness: Conventional excipients often fail to generate adequate tablet hardness.
• Friability: Weak compacts break, chip, or shed powder, leading to quality failures.

STRATEGIC RESPONSE

• Enhanced powder flow and ensures smooth, uniform die filling.
• Enables strong tablet formation even with difficult to compact materials.
• Offers low moisture behaviour that helps reduce sticking, clumping, and stability issues.
• Strengthens tablets at lower compression forces for improved durability.
• Creates cohesive tablets that resist chipping, breaking, and dusting.
• Boost efficiency with cost effective process

COMPARISON OF COMPRESSOL™ PROTAB WITH COMPETITOR’S PLATFORM

A trial conducted to evaluate the Compressol ProTab performance and compared with market competitors to assess relative performance.

Formula details for comparative evaluation

RESULTS

See the full technical brochure on Compressol™ ProTab in Diosmin Applications here

(click the picture to download the brochure)

Source: SPI Pharma, technical brochure Compressol™ ProTab in Diosmin Applications

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