ZoomLab® Phase Diagram of Solid Dispersion

Exciting news for ZoomLab® users interested in formulating solid dispersions: You can now evaluate the interaction of binary drug-polymer mixtures with the new
“Solid Dispersion Phase Diagram” app!
The new app will be available to all ZoomLab® users free of charge until March 2025, then will become part of the ZoomLab® Premium Account portfolio.
Solid dispersions are a suitable formulation approach for many poorly soluble active ingredients. Stabilizing the active ingredient in an amorphous physical form with the help of a pharmaceutical polymer can increase their solubility and oral bioavailability. To achieve and stabilize a high drug load, a favorable interaction between the active ingredient and the polymer is desired.
Formulators can perform a virtual screening with our new ZoomLab® app. The extent of interaction in a binary drug-polymer mixture can be evaluated, and several aspects can be assessed in detail:
- Explore predicted phase diagrams showing the solid-liquid equilibrium line and glass transition temperatures for all active ingredient weight fractions.
- Evaluate the feasibility of your target drug loading as well as the kinetic stability of your prototype formulation at room temperature.
- Identify the impact and contribution of individual monomers of the selected polymer on the total extent of interaction.
Read more here and in the PDF below:
BASF’s Virtual Pharma Assistant ZoomLab® now includes a new app that helps formulators evaluate the interaction of an active ingredient with pharmaceutical polymers for formulating a solid dispersion.
Solid dispersions are a suitable formulation approach for many poorly soluble active ingredients. Stabilizing the active
ingredient in an amorphous physical form with the help of a pharmaceutical polymer can increase their solubility and oral bioavailability. To achieve and stabilize a high drug load, a favorable interaction between the active ingredient and the polymer is desired.
Formulators can perform a virtual screening with our new ZoomLab® app. The extent of interaction in a binary drug-polymer mixture can be evaluated, and several aspects such as the feasibility of a target drug loading or the kinetic stabilization potential can be assessed in detail.
Getting started
Find the “Phase Diagram of Solid Dispersion” app on the ZoomLab® dashboard or in the app repository.
You also can enter search terms, e.g., “solid dispersion” or “phase diagram”, to find the app.
Define the active ingredient

Select the pharmaceutical polymer and define the composition
3. Select a pharmaceutical polymer from the list of available polymers.
The extent of interaction between theactive ingredient and the selected polymer in a binary mixture will be evaluated. Optionally, define a target weight fraction for your active ingredient in the formulation.
The app will evaluate the feasibility and stability of the formulation based on the target composition.
Evaluate the results
4. The algorithm will evaluate the thermodynamic and kinetic stability of the formulation.
The detailed result table provides an overview of the (predicted) input parameters as well as the most important result parameters such as maximum stable drug loading, glass transition temperature of the formulation or the predicted interaction parameter value.
5. The phase diagram graph shows the solid-liquid equilibrium line (SLE) for the binary mixture. The SLE is interpreted as the thermodynamic solubility of the active ingredient in the polymer, depending on the composition and temperature. Alongside the SLE, a predicted glass transition temperature line is shown. Reference lines allow for an easy evaluation of the defined target profile. They show the target weight fraction at room temperature and the corresponding glass transition temperature of the mixture.

Reduce experimental trial and error in early formulation development and focus on the most promising candidates –
perform an initial, virtual screening with ZoomLab®’s Phase Diagram of Solid Dispersion app!

See the full brochure on ZoomLab® Phase Diagram of Solid Dispersion here
(click the picture to download the brochure)
Source: ZoomLab, website ZoomLab® Phase Diagram of Solid Dispersion, https://pharma.basf.com/about-basf-pharma/digitalization/zoomlab
You are interested in ZoomLab™? See the recorded webinar we did on 8ht of Nov. with BASF
and get an overview about ZoomLab 4.0: here:
