OCT

Abstract This study aimed to evaluate the feasibility of using ultrasound-assisted compression (USAC) for manufacturing implantable drug delivery systems (IDDS). USAC integrates the principles of traditional compression techniques with the application of ultrasound waves. The combined mechanical…
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Abstract Optical Coherence Tomography (OCT) has been reported as a promising technology for in-line monitoring of pharmaceutical film-coating processes, providing real-time information on actual tablet coating thicknesses and thickness variability, together enabling correlation modeling of the…
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In recent years, there has been a surge of research focused on in situ-forming implants as a method of localized drug delivery. Despite advancements, the predominant challenge in situ-forming solvent-induced phase inversion (SIPI) implants is significant burst release which typically occurs within…
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Abstract Intranasal drug delivery is a promising non-invasive method for administering both local and systemic medications. While previous studies have extensively investigated the effects of particle size, airflow dynamics, and deposition locations on deposition efficiency, they have not focused…
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Abstract Optical coherence tomography (OCT) has emerged as an in-line monitoring technique for pharmaceutical coating processes based on a representative number of samples. In this study, an approach was developed to correlate the coating thickness measured in-line via OCT with the resultant…
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In-line monitoring of critical quality attributes (CQAs) during a tableting process is an essential step toward a real-time release strategy. Such CQAs can be the tablet mass, the API content, dissolution, hardness and tensile strength. Since dissolution testing is laborious and time-consuming and…
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Film-coated modified-release tablets are an important dosage form amenable to targeted, controlled, or delayed drug release in the specific region of the gastrointestinal (GI) tract. Depending on the film composition and interaction with the GI fluid, such coated products can modulate the local…
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Microneedles (MNs) are micron-sized needles, typically <2 mm in length, arranged either as an array or as single needle. These MNs offer a minimally invasive approach to ocular drug delivery due to their micron size (reducing tissue damage compared to that of hypodermic needles) and overcoming…
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Coating thickness is a critical quality attribute of many coated tablets. Functional coatings ensure correct drug release kinetics or protection from light, while non-functional coatings are generally applied for cosmetic reasons. Traditionally, coating thickness is assessed indirectly via offline…
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Abstract Purpose The thickness and other quality aspects of pharmaceutical coatings can be significantly impacted by coating process conditions. Under certain circumstances, they can notably influence the drug product performance such as dissolution profiles. Typically, a target coating…
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