OCT

Coating thickness is a critical quality attribute of many coated tablets. Functional coatings ensure correct drug release kinetics or protection from light, while non-functional coatings are generally applied for cosmetic reasons. Traditionally, coating thickness is assessed indirectly via offline…
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Abstract Purpose The thickness and other quality aspects of pharmaceutical coatings can be significantly impacted by coating process conditions. Under certain circumstances, they can notably influence the drug product performance such as dissolution profiles. Typically, a target coating…
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Information on the penetration depth, pathways, metabolization, storage of vehicles, active pharmaceutical ingredients (APIs), and functional cosmetic ingredients (FCIs) of topically applied formulations or contaminants (substances) in skin is of great importance for understanding their interaction…
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Abstract Real-time prediction of the dissolution behavior of solid oral dosage forms is an important research topic. Although methods such as Terahertz and Raman can provide measurements that can be linked to the dissolution performance, they typically require a longer time off-line for analysis.…
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Abstract Co-extruded core-membrane formulations have been extensively explored as long-acting subcutaneous implants or vaginal inserts, guaranteeing zero-order release. Although the membrane thickness and homogeneity determine the final drug release, these parameters are still evaluated offline via…
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Abstract Achieving an even coating distribution on tablets during the coating process can be challenging, not to mention the challenges of accurately measuring and quantifying inter-tablet coating variability. Computer simulations using the Discrete Element Method (DEM) provide a viable pathway…
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Abstract Co-extruded core-membrane formulations have been extensively explored as long-acting subcutaneous implants or vaginal inserts, guaranteeing zero-order release. Although the membrane thickness and homogeneity determine the final drug release, these parameters are still evaluated offline via…
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Melasma is a common hyperpigmented skin condition that occurs on the face and other areas prone to light exposure, seriously affecting people's quality of life. Microneedle, a new type of transdermal drug delivery device, can significantly improve skin permeability. In this study, we designed and…
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Skin is considered as an attractive route for variety of drug molecule administration. However, it is proved to be the main physical barrier for drug flux owing to their poor permeability and low bioavailability across stratum corneum layer. In the current study, novel approach has been used to…
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Enteric coatings are designed to protect active pharmaceutical ingredients (APIs) against untimely release in the stomach. Acid protection of such coatings depends on the coating layer thickness and integrity, which must be determined in an accurate and reliable way to ensure the final product’s…
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