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OCT
Feasibility of In-line monitoring of critical coating quality attributes via OCT: Thickness,…
The feasibility of Optical Coherence Tomography (OCT) for in-line monitoring of pharmaceutical film coating processes has recently been demonstrated. OCT enables real-time acquisition of high-resolution cross-sectional images of coating layers and computation of coating thickness. In addition,…
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Feasibility of In-line monitoring of critical coating quality attributes via OCT: Thickness,…
The feasibility of Optical Coherence Tomography (OCT) for in-line monitoring of pharmaceutical film coating processes has recently been demonstrated. OCT enables real-time acquisition of high-resolution cross-sectional images of coating layers and computation of coating thickness. In addition,…
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Non-intrusive high resolution in-vitro measurement of regional drug powder deposition
Optical Coherence Tomography (OCT) is a high-resolution and non-invasive cross-sectional imaging technique mainly used for medical imaging and industrial non-destructive testing. However, its feasibility in the quantification of pulmonary drug deposition has not been investigated.
In this study,…
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Advanced Tablet Coating Development: Applying Optical Coherence Tomography (OCT) as a PAT Tool for…
Purpose: Novel tablet coating approaches include the development of continuous coating technologies. This requires a high level of automation to assure the quality and safety of the final coated product. Despite automation of control procedures also approaches of in-line process analytical…
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At-line Validation of Optical Coherence Tomography as In-line/At-line Coating Thickness Measurement…
Optical Coherence Tomography (OCT) is a promising technology for monitoring of pharmaceutical coating processes.
However, the pharmaceutical development and manufacturing require a periodic validation of the sensor’s accuracy. For this purpose, we propose polyethylene terephthalate (PET) films as…
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Measurement of granule layer thickness in a spouted bed coating process via optical coherence…
In this work a recently developed in-line measurement technique for monitoring of coating thickness was applied to a spray-coating process in a three-dimensional prismatic spouted bed.
The layer thickness was quantified with an optical coherence tomography (OCT) sensor positioned in front of the…
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Shedding Light on Coatings
Real-time Monitoring of Coating Quality at Industrial Scale
Optical Coherence Tomography (OCT) is increasingly being used for studies of pharmaceutical film coating. OCT allows fast and non-destructive analysis of the coating thickness and quality via high-resolution cross-sectional images.…
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Optical coherence tomography as a novel tool for in-line monitoring of a pharmaceutical film-coating…
Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool for monitoring pharmaceutical film-coated tablets. OCT…
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Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography
The paper presents a new in-line measurement technique for determining the coating thickness and uniformity of pharmaceutical pellets during film-coating in a fluid-bed apparatus. Non-destructive and contact-free process monitoring was performed via an optical coherence tomography (OCT) sensor…
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PAT process analysers in monitoring of film coating processes
14. October 2017
Over the last two decades, regulatory agencies have demanded better understanding of pharmaceutical products and processes by implementing new technological approaches, such as processanalytical technology (PAT). Process analysers present a key PAT tool, which…
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