Pharma Excipients
Sugars
Analyzing the interparticle batch homogeneity of natural hot-melt coatings
Abstract
The hot-melt coating process is widely used in the food and pharmaceutical industries. Its purpose of use is very diverse and includes, among other things, changing the functional properties of the particle surfaces, forming a protective layer or influencing the release rate of the…
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Lyophilization for Formulation Optimization of Drug-Loaded Thermoresponsive Polyelectrolyte Complex…
The lyophilization of nanogels is practical not only for their long-term conservation but also for adjusting their concentration and dispersant type during reconstitution for different applications. However, lyophilization strategies must be adapted to each kind of nanoformulation in order to…
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Development, Quality by Design-Based Optimization, and Stability Assessment of Oral Liquid…
The absence of oral liquid pharmaceutical forms appropriate for use in pediatric and adult patients with difficulty swallowing is a public health problem, especially in the hospital context. Baclofen is a muscle relaxant of choice for treating spasticity, generally marketed only in tablet form,…
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Molecular Basis of Sweetness, Recent Concepts, an Ideal Sweetener and Saccharide and Non-saccharide…
Understanding of the sweetness of an organic or inorganic substance is complex process and it is ingrained with the intricacies of psychological perception, molecular structure, chemical nature and environmental conditions e.g. pH, temperature, type of medium etc. Sucrose tastes sweet but when it is…
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Encapsulation of polyphenols in pH-responsive micelles self-assembled from octenyl-succinylated…
An amphiphilic polymer based on octenyl succinic anhydride-modified curdlan oligosaccharide (MCOS) was synthesized. The critical micelle concentration of MCOS was 3.91 μg·mL−1. MCOS could self-assemble into spherical micelles with a particle size of 230.1 nm and a zeta potential of − 37.9 mV. When…
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Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of…
The paediatric population has always suffered from a lack of medicines tailored to their needs, especially in terms of accurate dosage, stability and acceptability. Orodispersible dosage forms have gone through a resurrection as an alternative to liquid formulations or fractioned solid formulations,…
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Diboronate crosslinking: Introducing glucose specificity in glucose-responsive dynamic-covalent…
Dynamic-covalent motifs are increasingly used for hydrogel crosslinking, leveraging equilibrium-governed reversible bonds to prepare viscoelastic materials with dynamic properties and self-healing character. The bonding between aryl boronates and diols is one dynamic-covalent chemistry of interest.…
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Formulation, Optimization and Evaluation of Ticagrelor Loaded Self Microemulsifying Chewable Tablets
Ticagrelor is a new generation Adenosine diphosphate receptor inhibitor drug which is highly lipohilic having poor aqueous solubility used in the treatment of Acute Coronary Syndrome and prevention of Thrombotic events like Stroke and Heart Attack. An approach has been made to develop Chewable…
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Carbohydrates Used in Polymeric Systems for Drug Delivery: From Structures to Applications
Abstract
Carbohydrates, one of the most important compounds in living organisms, perform numerous roles, including those associated with the extracellular matrix, energy-related compounds, and information. Of these, polymeric carbohydrates are a class of substance with a long history in drug…
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Advances in the Treatment of Inflammatory Bowel Disease: Focus on Polysaccharide Nanoparticulate…
The complex pathogenesis of inflammatory bowel disease (IBD) explains the many hurdles for finding an efficient approach to cure it. Nowadays, therapeutic protocols aim to reduce inflammation during the hot phase or maintain remission during the cold phase. Nonetheless, these drugs suffer from…
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