Pharma Excipients
Sugars
Pharmatrans SANAQ® Sugar Spheres and MCC pellet excipients for controlled release
Recent trends have emphasised that multi-particulate drug delivery systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric…
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Phase behaviour and characterization of micelles of graft copolymer Soluplus® and non-ionic…
The present study deals with the self-assembly of a pure graft copolymer: Soluplus® and a non-ionic surfactant: Solutol® HS15 and focuses on their clouding behaviour in the presence of different additives viz. inorganic salts (NaF, NaCl, NaBr, NaI, NaNO3, KCl, KBr, KI), bile salts (sodium…
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Impact of Formulation on the Quality and Stability of Freeze-dried Nanoparticles
Freeze-drying is an effective approach to improve the long-term stability of nanomedicines. Lyoprotectants are generally considered as requisite excipients to ensure that the quality of nanoparticles is maintained throughout the freeze-drying process. However, depending on the type of nanoparticles,…
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Development of Fully Redispersible Dried Nanocrystals by Using Sucrose Laurate as Stabilizer for…
There is much interest in converting poorly water-soluble drugs into nanocrystals as they provide extremely high surface area that increases dissolution rate and oral bioavailability. However, nanocrystals are prepared as aqueous suspensions, and once the suspensions are dried for development of…
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Fate of Tableted Freeze-Dried siRNA Lipoplexes in Gastrointestinal Environment
The incorporation of siRNA into nanocarriers is mandatory to facilitate its intracellular delivery, as siRNA itself cannot enter cells. However, the incorporation of these nanocarriers into oral, solid dosage forms and their fate in the gastrointestinal environment is yet to be explored. In the…
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Biologic excipients: Importance of clinical awareness of inactive ingredients
Due to the complexity and fragility of biological drug products, several challenges exist in their formulation development. Excipients are added to increase product stability, maintain tonicity, and facilitate drug delivery. The potential implications of these additive substances merit clinical…
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Thin-film freeze-drying of a bivalent Norovirus vaccine while maintaining the potency of both…
A bivalent Norovirus vaccine candidate has been developed that contains Norovirus strain GI.1 Norwalk-virus like particles (VLP) and strain GII.4 Consensus VLPadsorbed on aluminum (oxy)hydroxide. The Norwalk and Consensus antigens have different stability profiles, making it challenging to prepare a…
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Development of mushroom polysaccharide and probiotics based solid self-nanoemulsifying drug delivery…
The role of mushroom polysaccharides and probiotics as pharmaceutical excipients for development of nanocarriers has never been explored. In the present study an attempt has been made to explore Ganoderma lucidum extract powder (GLEP) containing polysaccharides and probiotics to convert liquid self…
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Low-in-nanoparticulate-impurities sucrose for biopharmaceutical formulations
Purpose
Nanoparticle impurities (NPIs) with a size of 100–300 nm have recently been discovered in pharmaceutical-grade sucrose (Weinbuch et al., 2015). These can lead to false analytical results, as they mimic protein aggregates and can thus cause the potential exclusion of “lead molecules” during…
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Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation…
Spray-drying is an inherently continuous and well-established industrial drying process. It can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both an economic and health benefit. In this review, we cover a systematic assessment and discuss the spray-drying of…
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