Detachable-Dissolvable-Microneedle as a potent subunit vaccine delivery device that requires no cold-chain

2. November 2023

Although vaccine administration by microneedles has been demonstrated, delivery reliability issues have prevented their implementation. Through an ex vivo porcine skin experiment,...

Figure 2. Endothermic curves of F1 (A), F2 (B), F3 (C), F4 (D), F5 (E), F6 (F), F7 (G) IDP, insulin (H), trehalose (I), inulin (J), poloxamer 188 (K), and HPMC E5 (L).

Stability study of spray freeze-dried insulin dry powder formulations used for nose-to-brain delivery

1. November 2023

Insulin is classified as a cold chain product due to being a peptide hormone with stability issues in the liquid...

A dry powder formulation for peripheral lung delivery and absorption of an anti-SARS-CoV-2 ACE2 decoy polypeptide

31. October 2023

One of the strategies proposed for the neutralization of SARS-CoV-2 has been to synthetize small proteins able to act as...

Use of Excipients in Downstream Processing to Improve Protein Purification

25. October 2023

Excipients are used to improve the stability of protein-based therapeutics by protecting the protein against a range of stress conditions...

The synthesis of certain fatty acid ester derivatives of trehalose and an investigation of their emulsifying properties and bioactivities

21. October 2023

Bio-based surfactants exerting both functional and nutritional properties are needed in the food industry. This study reports the one-pot synthesis, using a...

Nagase/Hayashibara will be attending the AAPS 2023 PharmSci 360 in Orlando

10. October 2023

Press release Nagase/Hayashibara will be attending the AAPS 2023 PharmSci 360 in Orlando, FL, USA. AAPS 2023 PharmSci 360 in...

Structural modifications for the conversion of proteins and peptides into stable dried powder formulations: A review

10. October 2023

The drying of biomolecules into powdered formulations has become the main form of long-term product stabilisation, allowing for the delivery...

Lyophilized Lipid Liquid Crystalline Nanoparticles as an Antimicrobial Delivery System

14. September 2023

Lipid liquid crystalline nanoparticles (LCNPs) are unique nanocarriers that efficiently deliver antimicrobials through biological barriers. Yet, their wide application as...

Live Biotherapeutics: importance of formulation and lyophilization parametersand an example of a clinical application

6. September 2023

In recent years, probiotics have expanded from their traditional classification as “health promoting food” to the development of live biotherapeutic...

Nanoparticulate impurities in the pharmaceutical excipient trehalose induce an early immune response

6. July 2023

Abstract Background Pharmaceutical excipients are an important part of biological products. However, few attempts have been made to distinguish between...

Trehalose