The Impact of Formulation and Freeze Drying on the Properties and Performance of Freeze-Dried Limosilactobacillus reuteri R2LC

18. December 2023

Freeze drying is a commonly used method for preserving probiotic bacteria and live biotherapeutic products. Before drying, the bacterial cells...

Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

26. November 2023

Abstract Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such...

Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement

23. November 2023

Abstract Crystalline carriers such as dextrose, sucrose, galactose, mannitol, sorbitol, and isomalt have been reported to increase the solubility, and...

Process development and quality attributes for the freeze-drying process in pharmaceuticals, biopharmaceuticals and nanomedicine delivery: a state-of-the-art review

23. November 2023

Abstract Background Process intensification is a major hurdle in pharmaceutical process scale-up. Solvent removal strategies have limited the effectiveness of...

Detachable-Dissolvable-Microneedle as a potent subunit vaccine delivery device that requires no cold-chain

2. November 2023

Although vaccine administration by microneedles has been demonstrated, delivery reliability issues have prevented their implementation. Through an ex vivo porcine skin experiment,...

Figure 2. Endothermic curves of F1 (A), F2 (B), F3 (C), F4 (D), F5 (E), F6 (F), F7 (G) IDP, insulin (H), trehalose (I), inulin (J), poloxamer 188 (K), and HPMC E5 (L).

Stability study of spray freeze-dried insulin dry powder formulations used for nose-to-brain delivery

1. November 2023

Insulin is classified as a cold chain product due to being a peptide hormone with stability issues in the liquid...

A dry powder formulation for peripheral lung delivery and absorption of an anti-SARS-CoV-2 ACE2 decoy polypeptide

31. October 2023

One of the strategies proposed for the neutralization of SARS-CoV-2 has been to synthetize small proteins able to act as...

Use of Excipients in Downstream Processing to Improve Protein Purification

25. October 2023

Excipients are used to improve the stability of protein-based therapeutics by protecting the protein against a range of stress conditions...

The synthesis of certain fatty acid ester derivatives of trehalose and an investigation of their emulsifying properties and bioactivities

21. October 2023

Bio-based surfactants exerting both functional and nutritional properties are needed in the food industry. This study reports the one-pot synthesis, using a...

Nagase/Hayashibara will be attending the AAPS 2023 PharmSci 360 in Orlando

10. October 2023

Press release Nagase/Hayashibara will be attending the AAPS 2023 PharmSci 360 in Orlando, FL, USA. AAPS 2023 PharmSci 360 in...

Trehalose