Pharma Excipients
Acrylic Polymers
Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion…
The current study is aimed at the development of chrono modulated multiple unit particulate systems (MUPS) of nifedipine (ND) by a continuous double extrusion process. ND, a poorly soluble drug, was formulated into an amorphous solid dispersion (ASD) to improve its solubility. Further, the ASD was…
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Tuning of Paroxetine 3D-Printable Formulations for Fused Deposition Modelling
This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing. Polymeric matrices were used alone, or added with processing enhancers (e.g., plasticizer and filler). The polymeric formulation…
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3D Printing of Dapagliflozin Containing Self-Nanoemulsifying Tablets: Formulation Design and In…
The 3D printing techniques have been explored extensively in recent years for pharmaceutical manufacturing and drug delivery applications. The current investigation aims to explore 3D printing for the design and development of a nanomedicine-based oral solid dosage form of a poorly water-soluble…
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Solubility Enhancement of Diclofenac Using Solid Dispersions
The phenomenon which gives rise to a homogenous system, formed by the dissolution of solute in a solvent is known as solubility. Low solubility is the limiting factor in formulation development. Diclofenac being BCS class II drug have low aqueous solubility of 0.00401mg/ml. Amongst various…
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Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of…
The current study evaluated the effect of location and amount of various superdisintegrants on the properties of tablets made by twin-screw melt granulation (TSMG). Sodium-croscarmellose (CCS), crospovidone (CPV), and sodium starch glycolate (SSG) were used in various proportions intra- and…
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Anti-counterfeiting protection, personalized medicines − development of 2D identification methods…
Counterfeiting of the products for healing is as old as trading, and it is difficult to quantify the magnitude of the problem. It is known that substandard and/or falsified (SF) medicines are a growing global threat to health, and they cause serious social and economic damage. The EU has a strong…
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Feasibility of In-line monitoring of critical coating quality attributes via OCT: Thickness,…
The feasibility of Optical Coherence Tomography (OCT) for in-line monitoring of pharmaceutical film coating processes has recently been demonstrated. OCT enables real-time acquisition of high-resolution cross-sectional images of coating layers and computation of coating thickness. In addition,…
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Impact of hydrophilic binders on stability of lipid-based sustained release matrices of quetiapine…
Dose dumping is the major drawback of sustained release (SR) matrices. The current research aimed to develop the stable lipid-based SR matrices of quetiapine fumarate (QTF) using GeleolTM (glyceryl monostearate; GMS) as the lipid matrix carrier and KlucelTM EF (HPC EF), Kollidon® VA64, and Kollidon®…
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Efficacy of topical risedronate and risedronate – Eudragit E complex in a model of cutaneous…
An efficacious topical treatment for cutaneous leishmaniasis (CL) is highly desirable but still an ongoing challenge. Systemic risedronate (Ris) has been reported to have anti-leishmanial properties and Eudragit EPO (EuE) has shown in vitro activity against L. (L.) amazonensis. The aim of this work…
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Polymeric and Lipid Nanoparticles: Which Applications in Pediatrics?
This review aims to provide the state of the art on polymeric and lipid nanoparticles, used or suggested to approach pediatric diseases’ problems and needs, and to inspire new researches in this field. Several drugs are currently not available in formulations suitable for pediatric patients.…
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