Development of a Nanocrystal Formulation of a Low Melting Point API Following a Quality by Design Approach

4. June 2021

Preparation of nanocrystal formulations by wet media milling and spray-drying is a reliable technique to enhance dissolution and ameliorate absorption...

A Dry Powder Platform for Nose-To-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies

1. June 2021

Nasal route of administration offers a unique opportunity of brain targeted drug delivery via olfactory and trigeminal pathway, providing effective...

Pöllinger Webinar Multiparticulates 6 - Teaser

Multiparticulates – modern oral drug products for our society; Part 6: DoE case studies in QbD development

1. June 2021

In this webinar, Norbert Pöllinger presented a number of case studies showing how the pharmaceutical quality and processing times and...

Figure 1 of QbD Enabled Optimization of Solvent Shifting Method for Fabrication of PLGA Based Nanoparticles for Promising Delivery of Capecitabine for Antitumor Activity

QbD Enabled Optimization of Solvent Shifting Method for Fabrication of PLGA Based Nanoparticles for Promising Delivery of Capecitabine for Antitumor Activity

22. May 2021

The key objective of the current research was to fabricate and optimize Capecitabine loaded PLGA based nanoparticles (NPs) by enabling...

graphical abstract of Systematically designed chitosan-coated solid lipid nanoparticles of ferulic acid for effective management of Alzheimer’s disease: A preclinical evidence

Systematically designed chitosan-coated solid lipid nanoparticles of ferulic acid for effective management of Alzheimer’s disease: A preclinical evidence

21. May 2021

Ferulic acid (FA) is a ubiquitous natural plant bioactive with distinctive promise in neurodegenerative disorders. However, its therapeutic efficacy gets...

Critical Tools in Tableting Research: Using Compaction Simulator and Quality by Design (QbD) to Evaluate Lubricants’ Effect in Direct Compressible Formulation

15. May 2021

As commonly known, the product development stage is quite complex, requires intensive knowledge, and is time-consuming. The selection of the...

graphical abstract of Development, optimization and in-vivo evaluation of cyanocobalamin loaded orodispersible films using hot-melt extrusion technology: A quality by design (QbD) approach

Development, optimization and in-vivo evaluation of cyanocobalamin loaded orodispersible films using hot-melt extrusion technology: A quality by design (QbD) approach

7. May 2021

Vitamin B12 deficiency is associated with high risks of cognitive decline, neuropathy, megaloblastic anaemia and depression. Therefore, there is a...

MODCOS continuous high shear granulation process by Glatt

Advances in Twin-Screw Granulation Processing

5. May 2021

Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for...

graphical abstract of Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo evaluations

Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo evaluations

1. May 2021

The present study is concerned with the QbD-based design and development of luliconazole-loaded nanostructured lipid carriers (NLCs) hydrogel for enhanced...

graphical abstract of Continuous twin screw granulation Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach

Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach

1. April 2021

Despite significant advances in the research domain of continuous twin screw granulation, limited information is currently available on the impact of...

Quality by Design (QbD)