Roller Compaction

From minitablets to stick-packs: BENEO’s filler-binder galenIQ™ makes it easy for manufacturers to meet a growing need for convenient paediatric and geriatric delivery formats Different consumer groups have different requirements. The fact that we’re all unique drives innovation, particularly in…
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The relevance of the polymorphic form, particle size, and processing of mannitol for the mechanical properties of solid oral dosage forms was examined. Thus, particle and powder properties of spray granulated β D-mannitol, β D-mannitol, and δ D-mannitol were assessed in this study with regards to…
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Objective The aim of this study was to use an alternative granulation technique, solventless roll compaction, and to investigate the effect of the roll compaction pressure on the properties of granules and high-drug-loaded (80%, w/w) immediate release piracetam tablets. Significance…
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Abstract Continuous Manufacturing Technology continues to gain importance in pharmaceutical manufacturing. Although traditional processes like direct compression, roller compaction, or wet granulation are used within the continuous lines, the requirement for ingredients may differ from…
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Dry granulation via roller compaction is increasingly being used as granulation method for the production of oral solid dosage forms. Advantages of roller compaction include a simplified process compared to wet granulation and the inherently continuous nature of the process. A common problem of dry…
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Developing a robust roller compaction process can be challenging, due to the diversity in process parameters and material properties of the components in a formulation. A major challenge in dry granulation is the reduction of tablet strength as a result of re-compaction of the materials. The aim of…
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Roll compaction/ dry granulation is gaining importance. Numerous papers have been published and many attempts to model the process are available in the meantime. Johanson published a model in 1965, which is the basis for many further modifications until today. The aim of the paper is to improve…
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Granule size distribution (GSD) is one of the critical quality attributes in the roller compaction (RC) process. Determination of GSD for newly developed pharmaceutical compounds with unknown ribbon breakage behaviors at the RC milling step requires a quantitative insight into process parameters and…
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Isomalt is a polyol derived from sucrose. Advantages of this excipient are its sweet taste, which is supposed to allow taste masking, the low glycemic and insulinemic response (Petzoldt, 1982), and the ability to be compacted directly. With regard to infantile patients, also the lack of…
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In-die compression analysis is an effective method for the characterization of powder compressibility. However, physically unreasonable apparent solid fractions above one or apparent in-die porosities below zero are often calculated for higher compression stresses. One important reason for this…
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