Comparison of Proprietary and 3 Generic Formulation of Propofol for Induction of General Anesthesia
Background: This study compared the properties of propofol bolus for induction of general anesthesia between proprietary and 3 generic formulations, to assess if solvent differences had clinically relevant consequences on efficacy or side effects. Many studies have investigated different formulations of propofol for side effects, in this study we also focused on efficacy of different formulations for induction of general anesthesia.
Methods: 146 patients scheduled for general anesthesia received for induction one of the propofol formulations available in our country i.e. 35 had Propofol® Fresenius, 33 Propofol Dakota Pharm®, 40 Propofol Lipuro®, 38 Diprivan® injected in a peripheral venous catheter, and preceded by sufentanil 0.2 μg.kg-1. Airway control was based on intubation (n = 90, facilitated by atracurium), or laryngeal mask (n = 56). Efficacy was assessed by induction dose, ease of face mask ventilation and airway device insertion. Pain on injection, rash, or myoclonies were
recorded as side effects. Propofol formulations were compared by Anova or Chi 2 test.
Results: Expected hypnotic effects propofol injection were similar in the 4 groups, satisfying and consistent with previous publications.Pain on injection was present in 55% of patients (n = 81), mild in 36% (n = 54), and severe in 18% (n = 27). Myoclonies occurred in 4% of patients (n = 7) and local rash in 6% of patients (n = 10). Differences between formulations did not reach statistical significance.
Conclusion: The propofol formulations tested appeared similar on efficacy, with minor differences regarding side effects. No formulation could suppress totally pain on injection and associated treatment as lidocaine should be widely used.
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Motamed C, Delcour V, Laventure JP, Billard V. Comparison of Proprietary and 3 Generic Formulation of Propofol for Induction of General Anesthesia. Am J Anesth Clin Res. 2019;5(1): 001-005.