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Budenheim
Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation,…
The purpose of this study is to derive an optimal drug release formulation with human clinical bioequivalence in developing a sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixed-dose combination (FDC) tablet as a treatment for type 2 diabetes mellitus. As a treatment for type 2…
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Modeling die filling under gravity for different scales of rotary tablet presses
For tableting, die filling is an important process step as it directly influences the tablet weight and its variation, which is connected to the drug dose. However, the impact of process parameters and materials properties is not sufficiently understood until today, so process development and…
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Enhanced multi-component model to consider the lubricant effect on compressibility and…
Modeling of structural and mechanical tablet properties consisting of multiple components, based on a minimum of experimental data is of high interest, in order to minimize time- and cost-intensive experimental trials in the development of new tablet formulations. The majority of commonly available…
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A double-layered gastric floating tablet for zero-order controlled release of dihydromyricetin:…
Dihydromyricetin (DHM) is an important natural flavonoid. However, most of DHM preparations have shown shortcomings such as low drug loading, poor drug stability, and/or large fluctuations in blood concentration. This study aimed to develop a gastric floating tablet with a double-layered structure…
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Multivariate data analysis to evaluate commonly used compression descriptors
Numerous studies elucidated material behavior based on compression analyses. Especially compressibility, compactibility and tabletability were in the focus of these investigations. In the present study, a comprehensive multivariate data analysis was performed using principal component analysis…
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Effect of Process Parameters, Protectants and Carrier Materials on the Survival of Yeast Cells…
The administration of living microorganisms is of special interest, with regard to probiotic microorganisms providing health benefits to the patient. Effective dosage forms require the preservation of microbial viability until administration. Storage stability can be improved by drying, and the…
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The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS…
Sprinkle formulations represent an interesting concept of medicinal products aimed at the steadily growing population of patients suffering from swallowing difficulties (dysphagia). In the present work, immediate-release sprinkle MUPS (multiple-unit pellet system) containing rosuvastatin calcium as…
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Advanced image analytics to study powder mixing in a novel laboratory scale agitated filter dryer
Powder mixing unit operations are essential to the manufacturing of pharmaceutical drug substance and drug products. To model powder mixing, computational approaches have been used to evaluate mixing indices for different types of mixers, while also necessitating experimental methods for tracking of…
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Development of directly compressible formulations of Sitagliptin hydrochloride and Sitagliptin…
Direct compression is the simplest and most economical way to produce pharmaceutical tablets. Challenging API properties as e.g., poor powder flow or compactibility can limit or even restrict the use of direct compression technology. In this webinar the development of a direct compression…
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Evaluation of alternative methods to derive particle density from compression data
The determination of particle density is a critical part of material characterization regarding compression analyses. Helium pycnometry as the most commonly used method is criticized for different aspects. Most prominent is the susceptibility to errors when measuring water-containing powders.…
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