Daicel

“Continuous Manufacturing (CM)” is a manufacturing method in which raw or blended materials are continuously charged to the processing line, and products are continuously discharged throughout the duration of the process. CM method is of great significance from the perspective of manufacturing…
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Pediatric formulations are strongly demanded from healthcare professionals and caregivers. Currently, solid dosage forms have been studied as pediatric preparations. In this article, we report the development of orally disintegrating tablets (ODTs) which shape are suitable for pediatric…
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HiSORAD is a state-of-the-art co-processed excipient for orally disintegrating tablets designed to have well-balanced property between orally disintegration time and tablet hardness. HiSORAD enables to produce ODTs by direct compression with three advantages: Practical flowability, excellent…
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The purpose of this work is to develop an orally disintegrating tablet (ODT) of sildenafil (SIL) using a materials sparing and expedited development approach, enabled by the materials science tetrahedron principle and predictive technologies. To overcome the problem of bitter taste of SIL, an…
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Orally disintegrating tablets (ODTs) are one of the most popular dosage forms for improving medication adherence. ODTs disintegrate in saliva in the oral cavity without requiring water. This allows patients with dysphagia, as well as geriatric and pediatric populations, to easily swallow the…
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Performance of orally disintegrating tablets (ODTs) with GRANFILLER-D was investigated by the real-time X-ray observation of water penetration into ODTs. Orally disintegrating tablets (ODTs) have gotten attention as they improve medication adherence for patients who have issues in swallowing,…
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HiSORAD is a state-of-the-art co-processed excipient for orally disintegrating tablets designed to have well-balanced property between oral disintegration time and tablet hardness. HiSORAD  is composed of three compendial grade excipients, D-Mannitol, Microcrystalline cellulose and Croscarmellose…
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Developing orally disintegrating tablets (ODTs) is a worldwide trend. In recent years, new excipients and excipient blends have enabled manufacturers to produce ODTs using conventional equipment, i.e., blenders and tablet presses. One such product is GRANFILLER-D, a co-processed excipient for direct…
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In recent years, multilayer tablets have drawn attention as dosage form that enable the production of combination drugs with API stability and precisely controlled dissolution rates, and many studies on such tablets have been reported. However, there are still few reports on the application of…
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In the manufacture of tablets, especially in direct tableting processes, the flowability of excipient powders and formulated powders is one of the most important characteristics. In the past two decades, orally disintegrating tablets (ODTs) have been prepared as popular solid dosage forms for…
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